A ferroptosis-targeting ceria anchored halloysite as orally drug delivery system for radiation colitis therapy

Yue Feng, Xiang Luo, Zichun Li, Xinjuan Fan, Yiting Wang, Rong-Rong He () and Mingxian Liu ()
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Yue Feng: Jinan University
Xiang Luo: Jinan University
Zichun Li: Jinan University
Xinjuan Fan: Sun Yat-sen University
Yiting Wang: Sun Yat-sen University
Rong-Rong He: Jinan University
Mingxian Liu: Jinan University

Nature Communications, 2023, vol. 14, issue 1, 1-17

Abstract: Abstract Radiation colitis is the leading cause of diarrhea and hematochezia in pelvic radiotherapy patients. This work advances the pathogenesis of radiation colitis from the perspective of ferroptosis. An oral Pickering emulsion is stabilized with halloysite clay nanotubes to alleviate radiation colitis by inhibiting ferroptosis. Ceria nanozyme grown in situ on nanotubes can scavenge reactive oxygen species, and deferiprone was loaded into the lumen of nanotubes to relieve iron stress. These two strategies effectively inhibit lipid peroxidation and rescue ferroptosis in the intestinal microenvironment. The clay nanotubes play a critical role as either a medicine to alleviate colitis, a nanocarrier that targets the inflamed colon by electrostatic adsorption, or an interfacial stabilizer for emulsions. This ferroptosis-based strategy was effective in vitro and in vivo, providing a prospective candidate for radiotherapy protection via rational regulation of specific oxidative stress.

Date: 2023
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DOI: 10.1038/s41467-023-40794-w

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