Metabolic glycan labeling immobilizes dendritic cell membrane and enhances antitumor efficacy of dendritic cell vaccine

Joonsu Han, Rimsha Bhatta, Yusheng Liu, Yang Bo, Alberto Elosegui-Artola and Hua Wang ()
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Joonsu Han: University of Illinois at Urbana-Champaign
Rimsha Bhatta: University of Illinois at Urbana-Champaign
Yusheng Liu: University of Illinois at Urbana-Champaign
Yang Bo: University of Illinois at Urbana-Champaign
Alberto Elosegui-Artola: Francis Crick Institute
Hua Wang: University of Illinois at Urbana-Champaign

Nature Communications, 2023, vol. 14, issue 1, 1-14

Abstract: Abstract Dendritic cell (DC) vaccine was among the first FDA-approved cancer immunotherapies, but has been limited by the modest cytotoxic T lymphocyte (CTL) response and therapeutic efficacy. Here we report a facile metabolic labeling approach that enables targeted modulation of adoptively transferred DCs for developing enhanced DC vaccines. We show that metabolic glycan labeling can reduce the membrane mobility of DCs, which activates DCs and improves the antigen presentation and subsequent T cell priming property of DCs. Metabolic glycan labeling itself can enhance the antitumor efficacy of DC vaccines. In addition, the cell-surface chemical tags (e.g., azido groups) introduced via metabolic glycan labeling also enable in vivo conjugation of cytokines onto adoptively transferred DCs, which further enhances CTL response and antitumor efficacy. Our DC labeling and targeting technology provides a strategy to improve the therapeutic efficacy of DC vaccines, with minimal interference upon the clinical manufacturing process.

Date: 2023
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DOI: 10.1038/s41467-023-40886-7

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