Self-triggered thermoelectric nanoheterojunction for cancer catalytic and immunotherapy

Xue Yuan, Yong Kang, Jinrui Dong, Ruiyan Li, Jiamin Ye, Yueyue Fan, Jingwen Han, Junhui Yu, Guangjian Ni, Xiaoyuan Ji () and Dong Ming
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Xue Yuan: Tianjin University
Yong Kang: Tianjin University
Jinrui Dong: Tianjin University
Ruiyan Li: Tianjin University
Jiamin Ye: Tianjin University
Yueyue Fan: Tianjin University
Jingwen Han: Tianjin University
Junhui Yu: Tianjin University
Guangjian Ni: Tianjin University
Xiaoyuan Ji: Tianjin University
Dong Ming: Tianjin University

Nature Communications, 2023, vol. 14, issue 1, 1-21

Abstract: Abstract The exogenous excitation requirement and electron-hole recombination are the key elements limiting the application of catalytic therapies. Here a tumor microenvironment (TME)-specific self-triggered thermoelectric nanoheterojunction (Bi0.5Sb1.5Te3/CaO2 nanosheets, BST/CaO2 NSs) with self-built-in electric field facilitated charge separation is fabricated. Upon exposure to TME, the CaO2 coating undergoes rapid hydrolysis, releasing Ca2+, H2O2, and heat. The resulting temperature difference on the BST NSs initiates a thermoelectric effect, driving reactive oxygen species production. H2O2 not only serves as a substrate supplement for ROS generation but also dysregulates Ca2+ channels, preventing Ca2+ efflux. This further exacerbates calcium overload-mediated therapy. Additionally, Ca2+ promotes DC maturation and tumor antigen presentation, facilitating immunotherapy. It is worth noting that the CaO2 NP coating hydrolyzes very slowly in normal cells, releasing Ca2+ and O2 without causing any adverse effects. Tumor-specific self-triggered thermoelectric nanoheterojunction combined catalytic therapy, ion interference therapy, and immunotherapy exhibit excellent antitumor performance in female mice.

Date: 2023
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DOI: 10.1038/s41467-023-40954-y

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