γδ T cells control murine skin inflammation and subcutaneous adipose wasting during chronic Trypanosoma brucei infection

Juan F. Quintana (), Matthew C. Sinton, Praveena Chandrasegaran, Agatha Nabilla Lestari, Rhiannon Heslop, Bachar Cheaib, John Ogunsola, Dieudonne Mumba Ngoyi, Nono-Raymond Kuispond Swar, Anneli Cooper, Neil A. Mabbott, Seth B. Coffelt and Annette MacLeod ()
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Juan F. Quintana: University of Glasgow
Matthew C. Sinton: University of Glasgow
Praveena Chandrasegaran: University of Glasgow
Agatha Nabilla Lestari: University of Glasgow
Rhiannon Heslop: University of Glasgow
Bachar Cheaib: University of Glasgow
John Ogunsola: University of Glasgow
Dieudonne Mumba Ngoyi: National Institute of Biomedical Research
Nono-Raymond Kuispond Swar: University of Glasgow
Anneli Cooper: University of Glasgow
Neil A. Mabbott: University of Edinburgh
Seth B. Coffelt: University of Glasgow
Annette MacLeod: University of Glasgow

Nature Communications, 2023, vol. 14, issue 1, 1-17

Abstract: Abstract African trypanosomes colonise the skin to ensure parasite transmission. However, how the skin responds to trypanosome infection remains unresolved. Here, we investigate the local immune response of the skin in a murine model of infection using spatial and single cell transcriptomics. We detect expansion of dermal IL-17A-producing Vγ6+ cells during infection, which occurs in the subcutaneous adipose tissue. In silico cell-cell communication analysis suggests that subcutaneous interstitial preadipocytes trigger T cell activation via Cd40 and Tnfsf18 signalling, amongst others. In vivo, we observe that female mice deficient for IL-17A-producing Vγ6+ cells show extensive inflammation and limit subcutaneous adipose tissue wasting, independently of parasite burden. Based on these observations, we propose that subcutaneous adipocytes and Vγ6+ cells act in concert to limit skin inflammation and adipose tissue wasting. These studies provide new insights into the role of γδ T cell and subcutaneous adipocytes as homeostatic regulators of skin immunity during chronic infection.

Date: 2023
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DOI: 10.1038/s41467-023-40962-y

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