Cell-inspired design of cascade catalysis system by 3D spatially separated active sites

Qiuping Wang, Kui Chen, Hui Jiang, Cai Chen, Can Xiong, Min Chen, Jie Xu, Xiaoping Gao (), Suowen Xu (), Huang Zhou () and Yuen Wu ()
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Qiuping Wang: University of Science and Technology of China
Kui Chen: University of Science and Technology of China
Hui Jiang: University of Science and Technology of China
Cai Chen: University of Science and Technology of China
Can Xiong: University of Science and Technology of China
Min Chen: University of Science and Technology of China
Jie Xu: Wenzhou University
Xiaoping Gao: University of Science and Technology of China
Suowen Xu: University of Science and Technology of China
Huang Zhou: University of Science and Technology of China
Yuen Wu: University of Science and Technology of China

Nature Communications, 2023, vol. 14, issue 1, 1-10

Abstract: Abstract Cells possess isolated compartments that spatially confine different enzymes, enabling high-efficiency enzymatic cascade reactions. Herein, we report a cell-inspired design of biomimetic cascade catalysis system by immobilizing Fe single atoms and Au nanoparticles on the inner and outer layers of three-dimensional nanocapsules, respectively. The different metal sites catalyze independently and work synergistically to enable engineered and cascade glucose detection. The biomimetic catalysis system demonstrates ~ 9.8- and 2-fold cascade activity enhancement than conventional mixing and coplanar construction systems, respectively. Furthermore, the biomimetic catalysis system is successfully demonstrated for the colorimetric glucose detection with high catalytic activity and selectivity. Also, the proposed gel-based sensor is integrated with smartphone to enable real-time and visual determination of glucose. More importantly, the gel-based sensor exhibits a high correlation with a commercial glucometer in real samples detection. These findings provide a strategy to design an efficient biomimetic catalysis system for applications in bioassays and nanobiomedicines.

Date: 2023
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DOI: 10.1038/s41467-023-41002-5

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