Ecophysiology and interactions of a taurine-respiring bacterium in the mouse gut

Huimin Ye, Sabrina Borusak, Claudia Eberl, Julia Krasenbrink, Anna S. Weiss, Song-Can Chen, Buck T. Hanson, Bela Hausmann, Craig W. Herbold, Manuel Pristner, Benjamin Zwirzitz, Benedikt Warth, Petra Pjevac, David Schleheck, Bärbel Stecher and Alexander Loy ()
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Huimin Ye: University of Vienna
Sabrina Borusak: University of Konstanz
Claudia Eberl: Ludwig Maximilian University Munich
Julia Krasenbrink: University of Vienna
Anna S. Weiss: Ludwig Maximilian University Munich
Song-Can Chen: University of Vienna
Buck T. Hanson: University of Vienna
Bela Hausmann: Joint Microbiome Facility of the Medical University of Vienna and the University of Vienna
Craig W. Herbold: University of Vienna
Manuel Pristner: University of Vienna
Benjamin Zwirzitz: University of Vienna
Benedikt Warth: University of Vienna
Petra Pjevac: University of Vienna
David Schleheck: University of Konstanz
Bärbel Stecher: Ludwig Maximilian University Munich
Alexander Loy: University of Vienna

Nature Communications, 2023, vol. 14, issue 1, 1-15

Abstract: Abstract Taurine-respiring gut bacteria produce H2S with ambivalent impact on host health. We report the isolation and ecophysiological characterization of a taurine-respiring mouse gut bacterium. Taurinivorans muris strain LT0009 represents a new widespread species that differs from the human gut sulfidogen Bilophila wadsworthia in its sulfur metabolism pathways and host distribution. T. muris specializes in taurine respiration in vivo, seemingly unaffected by mouse diet and genotype, but is dependent on other bacteria for release of taurine from bile acids. Colonization of T. muris in gnotobiotic mice increased deconjugation of taurine-conjugated bile acids and transcriptional activity of a sulfur metabolism gene-encoding prophage in other commensals, and slightly decreased the abundance of Salmonella enterica, which showed reduced expression of galactonate catabolism genes. Re-analysis of metagenome data from a previous study further suggested that T. muris can contribute to protection against pathogens by the commensal mouse gut microbiota. Together, we show the realized physiological niche of a key murine gut sulfidogen and its interactions with selected gut microbiota members.

Date: 2023
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DOI: 10.1038/s41467-023-41008-z

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