Functionalization and higher-order organization of liposomes with DNA nanostructures

Zhao Zhang (), Zhaomeng Feng, Xiaowei Zhao, Dominique Jean, Zhiheng Yu and Edwin R. Chapman ()
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Zhao Zhang: University of Wisconsin−Madison
Zhaomeng Feng: University of Wisconsin−Madison
Xiaowei Zhao: Janelia Research Campus, 19700 Helix Drive
Dominique Jean: Janelia Research Campus, 19700 Helix Drive
Zhiheng Yu: Janelia Research Campus, 19700 Helix Drive
Edwin R. Chapman: University of Wisconsin−Madison

Nature Communications, 2023, vol. 14, issue 1, 1-9

Abstract: Abstract Small unilamellar vesicles (SUVs) are indispensable model membranes, organelle mimics, and drug and vaccine carriers. However, the lack of robust techniques to functionalize or organize preformed SUVs limits their applications. Here we use DNA nanostructures to coat, cluster, and pattern sub-100-nm liposomes, generating distance-controlled vesicle networks, strings and dimers, among other configurations. The DNA coating also enables attachment of proteins to liposomes, and temporal control of membrane fusion driven by SNARE protein complexes. Such a convenient and versatile method of engineering premade vesicles both structurally and functionally is highly relevant to bottom-up biology and targeted delivery.

Date: 2023
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DOI: 10.1038/s41467-023-41013-2

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