Pathological pallidal beta activity in Parkinson’s disease is sustained during sleep and associated with sleep disturbance

Zixiao Yin, Ruoyu Ma, Qi An, Yichen Xu, Yifei Gan, Guanyu Zhu, Yin Jiang, Ning Zhang, Anchao Yang, Fangang Meng, Andrea A. Kühn, Hagai Bergman, Wolf-Julian Neumann () and Jianguo Zhang ()
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Zixiao Yin: Capital Medical University
Ruoyu Ma: Capital Medical University
Qi An: Capital Medical University
Yichen Xu: Capital Medical University
Yifei Gan: Capital Medical University
Guanyu Zhu: Capital Medical University
Yin Jiang: Capital Medical University
Ning Zhang: Capital Medical University
Anchao Yang: Capital Medical University
Fangang Meng: Capital Medical University
Andrea A. Kühn: Charité – Universitätsmedizin Berlin
Hagai Bergman: The Hebrew University
Wolf-Julian Neumann: Charité – Universitätsmedizin Berlin
Jianguo Zhang: Capital Medical University

Nature Communications, 2023, vol. 14, issue 1, 1-12

Abstract: Abstract Parkinson’s disease (PD) is associated with excessive beta activity in the basal ganglia. Brain sensing implants aim to leverage this biomarker for demand-dependent adaptive stimulation. Sleep disturbance is among the most common non-motor symptoms in PD, but its relationship with beta activity is unknown. To investigate the clinical potential of beta activity as a biomarker for sleep quality in PD, we recorded pallidal local field potentials during polysomnography in PD patients off dopaminergic medication and compared the results to dystonia patients. PD patients exhibited sustained and elevated beta activity across wakefulness, rapid eye movement (REM), and non-REM sleep, which was correlated with sleep disturbance. Simulation of adaptive stimulation revealed that sleep-related beta activity changes remain unaccounted for by current algorithms, with potential negative outcomes in sleep quality and overall quality of life for patients.

Date: 2023
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DOI: 10.1038/s41467-023-41128-6

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