Comprehensive proteomics and meta-analysis of COVID-19 host response

Haris Babačić (), Wanda Christ, José Eduardo Araújo, Georgios Mermelekas, Nidhi Sharma, Janne Tynell, Marina García, Renata Varnaite, Hilmir Asgeirsson, Hedvig Glans, Janne Lehtiö, Sara Gredmark-Russ, Jonas Klingström and Maria Pernemalm ()
Additional contact information
Haris Babačić: Karolinska Institutet
Wanda Christ: Karolinska Institutet
José Eduardo Araújo: Karolinska Institutet
Georgios Mermelekas: Karolinska Institutet
Nidhi Sharma: Karolinska Institutet
Janne Tynell: Karolinska Institutet
Marina García: Karolinska Institutet
Renata Varnaite: Karolinska Institutet
Hilmir Asgeirsson: Karolinska University Hospital
Hedvig Glans: Karolinska Institutet
Janne Lehtiö: Karolinska Institutet
Sara Gredmark-Russ: Karolinska Institutet
Jonas Klingström: Karolinska Institutet
Maria Pernemalm: Karolinska Institutet

Nature Communications, 2023, vol. 14, issue 1, 1-18

Abstract: Abstract COVID-19 is characterised by systemic immunological perturbations in the human body, which can lead to multi-organ damage. Many of these processes are considered to be mediated by the blood. Therefore, to better understand the systemic host response to SARS-CoV-2 infection, we performed systematic analyses of the circulating, soluble proteins in the blood through global proteomics by mass-spectrometry (MS) proteomics. Here, we show that a large part of the soluble blood proteome is altered in COVID-19, among them elevated levels of interferon-induced and proteasomal proteins. Some proteins that have alternating levels in human cells after a SARS-CoV-2 infection in vitro and in different organs of COVID-19 patients are deregulated in the blood, suggesting shared infection-related changes.The availability of different public proteomic resources on soluble blood proteome alterations leaves uncertainty about the change of a given protein during COVID-19. Hence, we performed a systematic review and meta-analysis of MS global proteomics studies of soluble blood proteomes, including up to 1706 individuals (1039 COVID-19 patients), to provide concluding estimates for the alteration of 1517 soluble blood proteins in COVID-19. Finally, based on the meta-analysis we developed CoViMAPP, an open-access resource for effect sizes of alterations and diagnostic potential of soluble blood proteins in COVID-19, which is publicly available for the research, clinical, and academic community.

Date: 2023
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DOI: 10.1038/s41467-023-41159-z

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