Contribution of common and rare variants to Asian neovascular age-related macular degeneration subtypes

Qiao Fan (), Hengtong Li, Xiaomeng Wang, Yih-Chung Tham, Kelvin Yi Chong Teo, Masayuki Yasuda, Weng Khong Lim, Yuet Ping Kwan, Jing Xian Teo, Ching-Jou Chen, Li Jia Chen, Jeeyun Ahn, Sonia Davila, Masahiro Miyake, Patrick Tan, Kyu Hyung Park, Chi Pui Pang, Chiea Chuan Khor, Tien Yin Wong, Yasuo Yanagi, Chui Ming Gemmy Cheung and Ching-Yu Cheng ()
Additional contact information
Qiao Fan: National University of Singapore
Hengtong Li: Singapore National Eye Centre
Xiaomeng Wang: Duke-NUS Medical School
Yih-Chung Tham: Duke-NUS Medical School
Kelvin Yi Chong Teo: Duke-NUS Medical School
Masayuki Yasuda: Tohoku University Graduate School of Medicine
Weng Khong Lim: SingHealth Duke-NUS Institute of Precision Medicine
Yuet Ping Kwan: Duke-NUS Medical School
Jing Xian Teo: SingHealth Duke-NUS Institute of Precision Medicine
Ching-Jou Chen: National University of Singapore
Li Jia Chen: The Chinese University of Hong Kong
Jeeyun Ahn: Seoul National University College of Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center
Sonia Davila: SingHealth Duke-NUS Institute of Precision Medicine
Masahiro Miyake: Kyoto University Graduate School of Medicine
Patrick Tan: SingHealth Duke-NUS Institute of Precision Medicine
Kyu Hyung Park: Seoul National University Hospital
Chi Pui Pang: The Chinese University of Hong Kong
Chiea Chuan Khor: Genome Institute of Singapore
Tien Yin Wong: Tsinghua University
Yasuo Yanagi: Yokohama City University
Chui Ming Gemmy Cheung: Duke-NUS Medical School
Ching-Yu Cheng: Duke-NUS Medical School

Nature Communications, 2023, vol. 14, issue 1, 1-14

Abstract: Abstract Neovascular age-related macular degeneration (nAMD), along with its clinical subtype known as polypoidal choroidal vasculopathy (PCV), are among the leading causes of vision loss in elderly Asians. In a genome-wide association study (GWAS) comprising 3,128 nAMD (1,555 PCV and 1,573 typical nAMD), and 5,493 controls of East Asian ancestry, we identify twelve loci, of which four are novel ( $$P \,

Date: 2023
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DOI: 10.1038/s41467-023-41256-z

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