The spatial and temporal structure of neural activity across the fly brain

Evan S. Schaffer (), Neeli Mishra, Matthew R. Whiteway, Wenze Li, Michelle B. Vancura, Jason Freedman, Kripa B. Patel, Venkatakaushik Voleti, Liam Paninski, Elizabeth M. C. Hillman, L. F. Abbott and Richard Axel
Additional contact information
Evan S. Schaffer: Columbia University
Neeli Mishra: Columbia University
Matthew R. Whiteway: Columbia University
Wenze Li: Columbia University
Michelle B. Vancura: Columbia University
Jason Freedman: Columbia University
Kripa B. Patel: Columbia University
Venkatakaushik Voleti: Columbia University
Liam Paninski: Columbia University
Elizabeth M. C. Hillman: Columbia University
L. F. Abbott: Columbia University
Richard Axel: Columbia University

Nature Communications, 2023, vol. 14, issue 1, 1-15

Abstract: Abstract What are the spatial and temporal scales of brainwide neuronal activity? We used swept, confocally-aligned planar excitation (SCAPE) microscopy to image all cells in a large volume of the brain of adult Drosophila with high spatiotemporal resolution while flies engaged in a variety of spontaneous behaviors. This revealed neural representations of behavior on multiple spatial and temporal scales. The activity of most neurons correlated (or anticorrelated) with running and flailing over timescales that ranged from seconds to a minute. Grooming elicited a weaker global response. Significant residual activity not directly correlated with behavior was high dimensional and reflected the activity of small clusters of spatially organized neurons that may correspond to genetically defined cell types. These clusters participate in the global dynamics, indicating that neural activity reflects a combination of local and broadly distributed components. This suggests that microcircuits with highly specified functions are provided with knowledge of the larger context in which they operate.

Date: 2023
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DOI: 10.1038/s41467-023-41261-2

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