Panoramic analysis of coronaviruses carried by representative bat species in Southern China to better understand the coronavirus sphere

Yelin Han, Panpan Xu, Yuyang Wang, Wenliang Zhao, Junpeng Zhang, Shuyi Zhang, Jianwei Wang, Qi Jin () and Zhiqiang Wu ()
Additional contact information
Yelin Han: Chinese Academy of Medical Sciences & Peking Union Medical College
Panpan Xu: Chinese Academy of Medical Sciences & Peking Union Medical College
Yuyang Wang: Chinese Academy of Medical Sciences & Peking Union Medical College
Wenliang Zhao: Chinese Academy of Medical Sciences & Peking Union Medical College
Junpeng Zhang: Shenyang Agricultural University
Shuyi Zhang: Shenyang Agricultural University
Jianwei Wang: Chinese Academy of Medical Sciences & Peking Union Medical College
Qi Jin: Chinese Academy of Medical Sciences & Peking Union Medical College
Zhiqiang Wu: Chinese Academy of Medical Sciences & Peking Union Medical College

Nature Communications, 2023, vol. 14, issue 1, 1-20

Abstract: Abstract Bats, recognized as considerable reservoirs for coronaviruses (CoVs), serve as natural hosts for several highly pathogenic CoVs, including SARS-CoV and SARS-CoV-2. Investigating the bat CoV community provides insights into the origin for highly pathogenic CoVs and highlights bat CoVs with potential spillover risks. This study probes the evolution, recombination, host range, geographical distribution, and cross-species transmission characteristics of bat CoVs across China and its associated CoVs in other regions. Through detailed research on 13,064 bat samples from 14 provinces of China, 1141 CoV strains are found across 10 subgenera and one unclassified Alpha-CoV, generating 399 complete genome sequences. Within bat CoVs, 11 new CoV species are identified and 425 recombination events are detected. Bats in southern China, particularly in Yunnan province, exhibit a pronounced diversity of CoVs. Limited sampling and low detection rates exist for CoVs in Myotacovirus, Nyctacovirus, Hibecovirus, Nobecovirus in China. The genus Myotis is highlighted as a potential ancestral host for Alpha-CoV, with the genus Hipposideros suggested as a likely progenitor host for bat-associated Beta-CoV, indicating the complexity of cross-species transmission dynamics. Through the comprehensive analysis, this study enriches the understanding of bat CoVs and offers a valuable resource for future research.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-023-41264-z Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41264-z

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-41264-z

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().