Epigenome-wide association analysis of infant bronchiolitis severity: a multicenter prospective cohort study

Zhaozhong Zhu (), Yijun Li, Robert J. Freishtat, Juan C. Celedón, Janice A. Espinola, Brennan Harmon, Andrea Hahn, Carlos A. Camargo, Liming Liang and Kohei Hasegawa
Additional contact information
Zhaozhong Zhu: Harvard Medical School
Yijun Li: Harvard T.H.Chan School of Public Health
Robert J. Freishtat: Children’s National Hospital
Juan C. Celedón: University of Pittsburgh
Janice A. Espinola: Harvard Medical School
Brennan Harmon: Children’s National Hospital
Andrea Hahn: Children’s National Hospital
Carlos A. Camargo: Harvard Medical School
Liming Liang: Harvard T.H.Chan School of Public Health
Kohei Hasegawa: Harvard Medical School

Nature Communications, 2023, vol. 14, issue 1, 1-13

Abstract: Abstract Bronchiolitis is the most common lower respiratory infection in infants, yet its pathobiology remains unclear. Here we present blood DNA methylation data from 625 infants hospitalized with bronchiolitis in a 17-center prospective study, and associate them with disease severity. We investigate differentially methylated CpGs (DMCs) for disease severity. We characterize the DMCs based on their association with cell and tissues types, biological pathways, and gene expression. Lastly, we also examine the relationships of severity-related DMCs with respiratory and immune traits in independent cohorts. We identify 33 DMCs associated with severity. These DMCs are differentially methylated in blood immune cells. These DMCs are also significantly enriched in multiple tissues (e.g., lung) and cells (e.g., small airway epithelial cells), and biological pathways (e.g., interleukin-1-mediated signaling). Additionally, these DMCs are associated with respiratory and immune traits (e.g., asthma, lung function, IgE levels). Our study suggests the role of DNA methylation in bronchiolitis severity.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-023-41300-y Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41300-y

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-41300-y

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().