NEUROD1 reinforces endocrine cell fate acquisition in pancreatic development

Romana Bohuslavova, Valeria Fabriciova, Ondrej Smolik, Laura Lebrón-Mora, Pavel Abaffy, Sarka Benesova, Daniel Zucha, Lukas Valihrach, Zuzana Berkova, Frantisek Saudek and Gabriela Pavlinkova ()
Additional contact information
Romana Bohuslavova: Institute of Biotechnology CAS
Valeria Fabriciova: Institute of Biotechnology CAS
Ondrej Smolik: Institute of Biotechnology CAS
Laura Lebrón-Mora: Institute of Biotechnology CAS
Pavel Abaffy: Institute of Biotechnology CAS
Sarka Benesova: Institute of Biotechnology CAS
Daniel Zucha: Institute of Biotechnology CAS
Lukas Valihrach: Institute of Biotechnology CAS
Zuzana Berkova: Institute for Clinical and Experimental Medicine
Frantisek Saudek: Institute for Clinical and Experimental Medicine
Gabriela Pavlinkova: Institute of Biotechnology CAS

Nature Communications, 2023, vol. 14, issue 1, 1-20

Abstract: Abstract NEUROD1 is a transcription factor that helps maintain a mature phenotype of pancreatic β cells. Disruption of Neurod1 during pancreatic development causes severe neonatal diabetes; however, the exact role of NEUROD1 in the differentiation programs of endocrine cells is unknown. Here, we report a crucial role of the NEUROD1 regulatory network in endocrine lineage commitment and differentiation. Mechanistically, transcriptome and chromatin landscape analyses demonstrate that Neurod1 inactivation triggers a downregulation of endocrine differentiation transcription factors and upregulation of non-endocrine genes within the Neurod1-deficient endocrine cell population, disturbing endocrine identity acquisition. Neurod1 deficiency altered the H3K27me3 histone modification pattern in promoter regions of differentially expressed genes, which resulted in gene regulatory network changes in the differentiation pathway of endocrine cells, compromising endocrine cell potential, differentiation, and functional properties.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-023-41306-6 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41306-6

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-41306-6

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().