Solar ultraviolet B radiation promotes α-MSH secretion to attenuate the function of ILC2s via the pituitary–lung axis

Yuying Huang, Lin Zhu, Shipeng Cheng, Ranran Dai, Chunrong Huang, Yanyan Song, Bo Peng, Xuezhen Li, Jing Wen, Yi Gong, Yunqian Hu, Ling Qian, Linyun Zhu, Fengying Zhang, Li Yu, Chunyan Yi, Wangpeng Gu, Zhiyang Ling, Liyan Ma, Wei Tang (), Li Peng (), Guochao Shi (), Yaguang Zhang () and Bing Sun ()
Additional contact information
Yuying Huang: University of Chinese Academy of Sciences
Lin Zhu: University of Chinese Academy of Sciences
Shipeng Cheng: University of Chinese Academy of Sciences
Ranran Dai: Shanghai Jiao Tong University School of Medicine
Chunrong Huang: Shanghai Jiao Tong University School of Medicine
Yanyan Song: Shanghai Jiao Tong University School of Medicine
Bo Peng: Shanghai Jiao Tong University School of Medicine
Xuezhen Li: University of Chinese Academy of Sciences
Jing Wen: University of Chinese Academy of Sciences
Yi Gong: Huashan Hospital Affiliated to Fudan University
Yunqian Hu: Tongji University
Ling Qian: Fudan University
Linyun Zhu: Shanghai Putuo District Central Hospital
Fengying Zhang: Shanghai Putuo District People’s Hospital
Li Yu: Tongji University
Chunyan Yi: University of Chinese Academy of Sciences
Wangpeng Gu: University of Chinese Academy of Sciences
Zhiyang Ling: University of Chinese Academy of Sciences
Liyan Ma: University of Chinese Academy of Sciences
Wei Tang: Shanghai Jiao Tong University School of Medicine
Li Peng: Shanghai Meteorological Service
Guochao Shi: Shanghai Jiao Tong University School of Medicine
Yaguang Zhang: University of Chinese Academy of Sciences
Bing Sun: University of Chinese Academy of Sciences

Nature Communications, 2023, vol. 14, issue 1, 1-16

Abstract: Abstract The immunomodulatory effects of ultraviolet B (UVB) radiation in human diseases have been described. Whether type 2 lung inflammation is directly affected by solar ultraviolet (UV) radiation is not fully understood. Here, we show a possible negative correlation between solar UVB radiation and asthmatic inflammation in humans and mice. UVB exposure to the eyes induces hypothalamus-pituitary activation and α-melanocyte-stimulating hormone (α-MSH) accumulation in the serum to suppress allergic airway inflammation by targeting group 2 innate lymphoid cells (ILC2) through the MC5R receptor in mice. The α-MSH/MC5R interaction limits ILC2 function through attenuation of JAK/STAT and NF-κB signaling. Consistently, we observe that the plasma α-MSH concentration is negatively correlated with the number and function of ILC2s in the peripheral blood mononuclear cells (PBMC) of patients with asthma. We provide insights into how solar UVB radiation-driven neuroendocrine α-MSH restricts ILC2-mediated lung inflammation and offer a possible strategy for controlling allergic diseases.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-023-41319-1 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41319-1

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-41319-1

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().