Defining a TCF1-expressing progenitor allogeneic CD8+ T cell subset in acute graft-versus-host disease

Solhwi Lee, Kunhee Lee, Hyeonjin Bae, Kyungmin Lee, Junghwa Lee, Junhui Ma, Ye Ji Lee, Bo Ryeong Lee, Woong-Yang Park and Se Jin Im ()
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Solhwi Lee: Sungkyunkwan University School of Medicine
Kunhee Lee: Sungkyunkwan University School of Medicine
Hyeonjin Bae: Sungkyunkwan University School of Medicine
Kyungmin Lee: Sungkyunkwan University School of Medicine
Junghwa Lee: Sungkyunkwan University School of Medicine
Junhui Ma: Sungkyunkwan University School of Medicine
Ye Ji Lee: GENINUS Inc.
Bo Ryeong Lee: GENINUS Inc.
Woong-Yang Park: GENINUS Inc.
Se Jin Im: Sungkyunkwan University School of Medicine

Nature Communications, 2023, vol. 14, issue 1, 1-15

Abstract: Abstract Graft-versus-host disease (GvHD) is a severe complication of hematopoietic stem cell transplantation driven by activated allogeneic T cells. Here, we identify a distinct subset of T cell factor-1 (TCF1)+ CD8+ T cells in mouse allogeneic and xenogeneic transplant models of acute GvHD. These TCF1+ cells exhibit distinct characteristics compared to TCF1- cells, including lower expression of inhibitory receptors and higher expression of costimulatory molecules. Notably, the TCF1+ subset displays exclusive proliferative potential and could differentiate into TCF1- effector cells upon antigenic stimulation. Pathway analyses support the role of TCF1+ and TCF1- subsets as resource cells and effector cells, respectively. Furthermore, the TCF1+ CD8+ T cell subset is primarily present in the spleen and exhibits a resident phenotype. These findings provide insight into the differentiation of allogeneic and xenogeneic CD8+ T cells and have implications for the development of immunotherapeutic strategies targeting acute GvHD.

Date: 2023
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DOI: 10.1038/s41467-023-41357-9

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