CD8+ tissue-resident memory T-cell development depends on infection-matching regulatory T-cell types

Leandro Barros, Daryna Piontkivska, Patrícia Figueiredo-Campos, Júlia Fanczal, Sofia Pereira Ribeiro, Marta Baptista, Silvia Ariotti, Nuno Santos, Maria João Amorim, Cristina Silva Pereira, Marc Veldhoen () and Cristina Ferreira ()
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Leandro Barros: Faculdade de Medicina da Universidade de Lisboa, Av. Professor Egas Moniz
Daryna Piontkivska: Instituto de Tecnologia Química e Biológica António Xavier, Av. da República
Patrícia Figueiredo-Campos: Faculdade de Medicina da Universidade de Lisboa, Av. Professor Egas Moniz
Júlia Fanczal: Faculdade de Medicina da Universidade de Lisboa, Av. Professor Egas Moniz
Sofia Pereira Ribeiro: Faculdade de Medicina da Universidade de Lisboa, Av. Professor Egas Moniz
Marta Baptista: Faculdade de Medicina da Universidade de Lisboa, Av. Professor Egas Moniz
Silvia Ariotti: Faculdade de Medicina da Universidade de Lisboa, Av. Professor Egas Moniz
Nuno Santos: Instituto Gulbenkian de Ciência, Rua da Quinta Grande 6
Maria João Amorim: Instituto Gulbenkian de Ciência, Rua da Quinta Grande 6
Cristina Silva Pereira: Instituto de Tecnologia Química e Biológica António Xavier, Av. da República
Marc Veldhoen: Faculdade de Medicina da Universidade de Lisboa, Av. Professor Egas Moniz
Cristina Ferreira: Faculdade de Medicina da Universidade de Lisboa, Av. Professor Egas Moniz

Nature Communications, 2023, vol. 14, issue 1, 1-13

Abstract: Abstract Immunological memory is critical for immune protection, particularly at epithelial sites, which are under constant risk of pathogen invasions. To counter invading pathogens, CD8+ memory T cells develop at the location of infection: tissue-resident memory T cells (TRM). CD8+ T-cell responses are associated with type-1 infections and type-1 regulatory T cells (TREG) are important for CD8+ T-cell development, however, if CD8+ TRM cells develop under other infection types and require immune type-specific TREG cells is unknown. We used three distinct lung infection models, to show that type-2 helminth infection does not establish CD8+ TRM cells. Intracellular (type-1) and extracellular (type-3) infections do and rely on the recruitment of response type-matching TREG population contributing transforming growth factor-β. Nevertheless, type-1 TREG cells remain the most important population for TRM cell development. Once established, TRM cells maintain their immune type profile. These results may have implications in the development of vaccines inducing CD8+ TRM cells.

Date: 2023
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DOI: 10.1038/s41467-023-41364-w

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