Epithelial plasticity and innate immune activation promote lung tissue remodeling following respiratory viral infection

Andrew K. Beppu, Juanjuan Zhao, Changfu Yao, Gianni Carraro, Edo Israely, Anna Lucia Coelho, Katherine Drake, Cory M. Hogaboam, William C. Parks, Jay K. Kolls and Barry R. Stripp ()
Additional contact information
Andrew K. Beppu: Cedars-Sinai Medical Center
Juanjuan Zhao: Cedars-Sinai Medical Center
Changfu Yao: Cedars-Sinai Medical Center
Gianni Carraro: Cedars-Sinai Medical Center
Edo Israely: Cedars-Sinai Medical Center
Anna Lucia Coelho: Cedars-Sinai Medical Center
Katherine Drake: Cedars-Sinai Medical Center
Cory M. Hogaboam: Cedars-Sinai Medical Center
William C. Parks: Cedars-Sinai Medical Center
Jay K. Kolls: School of Medicine
Barry R. Stripp: Cedars-Sinai Medical Center

Nature Communications, 2023, vol. 14, issue 1, 1-16

Abstract: Abstract Epithelial plasticity has been suggested in lungs of mice following genetic depletion of stem cells but is of unknown physiological relevance. Viral infection and chronic lung disease share similar pathological features of stem cell loss in alveoli, basal cell (BC) hyperplasia in small airways, and innate immune activation, that contribute to epithelial remodeling and loss of lung function. We show that a subset of distal airway secretory cells, intralobar serous (IS) cells, are activated to assume BC fates following influenza virus infection. Injury-induced hyperplastic BC (hBC) differ from pre-existing BC by high expression of IL-22Ra1 and undergo IL-22-dependent expansion for colonization of injured alveoli. Resolution of virus-elicited inflammation results in BC to IS re-differentiation in repopulated alveoli, and increased local expression of protective antimicrobial factors, but fails to restore normal alveolar epithelium responsible for gas exchange.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/s41467-023-41387-3 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41387-3

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-41387-3

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().