Dual hypoxia-responsive supramolecular complex for cancer target therapy

Jian-Shuang Guo, Juan-Juan Li, Ze-Han Wang, Yang Liu, Yu-Xin Yue, Hua-Bin Li, Xiu-He Zhao, Yuan-Jun Sun, Ya-Hui Ding, Fei Ding, Dong-Sheng Guo (), Liang Wang () and Yue Chen
Additional contact information
Jian-Shuang Guo: Nankai University
Juan-Juan Li: Nankai University
Ze-Han Wang: Nankai University
Yang Liu: Nankai University
Yu-Xin Yue: Nankai University
Hua-Bin Li: Nankai University
Xiu-He Zhao: Nankai University
Yuan-Jun Sun: Nankai University
Ya-Hui Ding: Nankai University
Fei Ding: Nankai University
Dong-Sheng Guo: Nankai University
Liang Wang: Nankai University
Yue Chen: Nankai University

Nature Communications, 2023, vol. 14, issue 1, 1-13

Abstract: Abstract The prognosis with pancreatic cancer is among the poorest of any human cancer. One of the important factors is the tumor hypoxia. Targeting tumor hypoxia is considered a desirable therapeutic option. However, it has not been translated into clinical success in the treatment of pancreatic cancer. With enhanced cytotoxicities against hypoxic pancreatic cancer cells, BE-43547A2 (BE) may serve as a promising template for hypoxia target strategy. Here, based on rational modification, a BE prodrug (NMP-BE) is encapsulated into sulfonated azocalix[5]arene (SAC5A) to generate a supramolecular dual hypoxia-responsive complex NMP-BE@SAC5A. Benefited from the selective load release within cancer cells, NMP-BE@SAC5A markedly suppresses tumor growth at low dose in pancreatic cancer cells xenograft murine model without developing systemic toxicity. This research presents a strategy for the modification of covalent compounds to achieve efficient delivery within tumors, a horizon for the realization of safe and reinforced hypoxia target therapy using a simple approach.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-023-41388-2 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41388-2

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-41388-2

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().