Pre-activated nanoparticles with persistent luminescence for deep tumor photodynamic therapy in gallbladder cancer

Sarun Juengpanich, Shijie Li, Taorui Yang, Tianao Xie, Jiadong Chen, Yukai Shan, Jiyoung Lee, Ziyi Lu, Tianen Chen, Bin Zhang, Jiasheng Cao, Jiahao Hu, Jicheng Yu, Yanfang Wang, Win Topatana (), Zhen Gu (), Xiujun Cai () and Mingyu Chen ()
Additional contact information
Sarun Juengpanich: Zhejiang University
Shijie Li: Zhejiang University
Taorui Yang: Zhejiang Sci-Tech University
Tianao Xie: Zhejiang University
Jiadong Chen: Zhejiang University
Yukai Shan: Zhejiang University
Jiyoung Lee: Zhejiang University
Ziyi Lu: Zhejiang University
Tianen Chen: Zhejiang University
Bin Zhang: Zhejiang University
Jiasheng Cao: Zhejiang University
Jiahao Hu: Zhejiang University
Jicheng Yu: Zhejiang University
Yanfang Wang: Zhejiang University
Win Topatana: Zhejiang University
Zhen Gu: Zhejiang University
Xiujun Cai: Zhejiang University
Mingyu Chen: Zhejiang University

Nature Communications, 2023, vol. 14, issue 1, 1-16

Abstract: Abstract Phototherapy of deep tumors still suffers from many obstacles, such as limited near-infrared (NIR) tissue penetration depth and low accumulation efficiency within the target sites. Herein, stimuli-sensitive tumor-targeted photodynamic nanoparticles (STPNs) with persistent luminescence for the treatment of deep tumors are reported. Purpurin 18 (Pu18), a porphyrin derivative, is utilized as a photosensitizer to produce persistent luminescence in STPNs, while lanthanide-doped upconversion nanoparticles (UCNPs) exhibit bioimaging properties and possess high photostability that can enhance photosensitizer efficacy. STPNs are initially stimulated by NIR irradiation before intravenous administration and accumulate at the tumor site to enter the cells through the HER2 receptor. Due to Pu18 afterglow luminescence properties, STPNs can continuously generate ROS to inhibit NFκB nuclear translocation, leading to tumor cell apoptosis. Moreover, STPNs can be used for diagnostic purposes through MRI and intraoperative NIR navigation. STPNs exceptional antitumor properties combined the advantages of UCNPs and persistent luminescence, representing a promising phototherapeutic strategy for deep tumors.

Date: 2023
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DOI: 10.1038/s41467-023-41389-1

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