High-efficiency green management of potato late blight by a self-assembled multicomponent nano-bioprotectant

Yuxi Wang, Mingshan Li, Jiahan Ying, Jie Shen, Daolong Dou, Meizhen Yin, Stephen C. Whisson, Paul R. J. Birch, Shuo Yan () and Xiaodan Wang ()
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Yuxi Wang: China Agricultural University
Mingshan Li: China Agricultural University
Jiahan Ying: China Agricultural University
Jie Shen: China Agricultural University
Daolong Dou: China Agricultural University
Meizhen Yin: Beijing University of Chemical Technology
Stephen C. Whisson: James Hutton Institute
Paul R. J. Birch: James Hutton Institute
Shuo Yan: China Agricultural University
Xiaodan Wang: China Agricultural University

Nature Communications, 2023, vol. 14, issue 1, 1-10

Abstract: Abstract Potato late blight caused by Phytophthora infestans is a devastating disease worldwide. Unlike other plant pathogens, double-stranded RNA (dsRNA) is poorly taken up by P. infestans, which is a key obstacle in using dsRNA for disease control. Here, a self-assembled multicomponent nano-bioprotectant for potato late blight management is designed based on dsRNA and a plant elicitor. Nanotechnology overcomes the dsRNA delivery bottleneck for P. infestans and extends the RNAi protective window. The protective effect of nano-enabled dsRNA against infection arises from a synergistic mechanism that bolsters the stability of dsRNA and optimizes its effective intracellular delivery. Additionally, the nano-enabled elicitor enhances endocytosis and amplifies the systemic defense response of the plants. Co-delivery of dsRNA and an elicitor provides a protective effect via the two aspects of pathogen inhibition and elevated plant defense mechanisms. The multicomponent nano-bioprotectant exhibits superior control efficacy compared to a commercial synthetic pesticide in field conditions. This work proposes an eco-friendly strategy to manage devastating plant diseases and pests.

Date: 2023
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DOI: 10.1038/s41467-023-41447-8

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