C3N nanodots inhibits Aβ peptides aggregation pathogenic path in Alzheimer’s disease

Xiuhua Yin, Hong Zhou, Mengling Zhang, Juan Su, Xiao Wang, Sijie Li, Zaixing Yang (), Zhenhui Kang () and Ruhong Zhou ()
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Xiuhua Yin: Zhejiang University
Hong Zhou: Zhejiang University
Mengling Zhang: Soochow University
Juan Su: Soochow University
Xiao Wang: Soochow University
Sijie Li: Soochow University
Zaixing Yang: Zhejiang University
Zhenhui Kang: Soochow University
Ruhong Zhou: Zhejiang University

Nature Communications, 2023, vol. 14, issue 1, 1-15

Abstract: Abstract Despite the accumulating evidence linking the development of Alzheimer’s disease (AD) to the aggregation of Aβ peptides and the emergence of Aβ oligomers, the FDA has approved very few anti-aggregation-based therapies over the past several decades. Here, we report the discovery of an Aβ peptide aggregation inhibitor: an ultra-small nanodot called C3N. C3N nanodots alleviate aggregation-induced neuron cytotoxicity, rescue neuronal death, and prevent neurite damage in vitro. Importantly, they reduce the global cerebral Aβ peptides levels, particularly in fibrillar amyloid plaques, and restore synaptic loss in AD mice. Consequently, these C3N nanodots significantly ameliorate behavioral deficits of APP/PS1 double transgenic male AD mice. Moreover, analysis of critical tissues (e.g., heart, liver, spleen, lung, and kidney) display no obvious pathological damage, suggesting C3N nanodots are biologically safe. Finally, molecular dynamics simulations also reveal the inhibitory mechanisms of C3N nanodots in Aβ peptides aggregation and its potential application against AD.

Date: 2023
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DOI: 10.1038/s41467-023-41489-y

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