A plant cytorhabdovirus modulates locomotor activity of insect vectors to enhance virus transmission

Dong-Min Gao, Ji-Hui Qiao, Qiang Gao, Jiawen Zhang, Ying Zang, Liang Xie, Yan Zhang, Ying Wang, Jingyan Fu, Hua Zhang, Chenggui Han and Xian-Bing Wang ()
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Dong-Min Gao: China Agricultural University
Ji-Hui Qiao: China Agricultural University
Qiang Gao: China Agricultural University
Jiawen Zhang: China Agricultural University
Ying Zang: China Agricultural University
Liang Xie: China Agricultural University
Yan Zhang: China Agricultural University
Ying Wang: China Agricultural University
Jingyan Fu: China Agricultural University
Hua Zhang: China Agricultural University
Chenggui Han: China Agricultural University
Xian-Bing Wang: China Agricultural University

Nature Communications, 2023, vol. 14, issue 1, 1-13

Abstract: Abstract Transmission of many plant viruses relies on phloem-feeding insect vectors. However, how plant viruses directly modulate insect behavior is largely unknown. Barley yellow striate mosaic virus (BYSMV) is transmitted by the small brown planthopper (SBPH, Laodelphax striatellus). Here, we show that BYSMV infects the central nervous system (CNS) of SBPHs, induces insect hyperactivity, and prolongs phloem feeding duration. The BYSMV accessory protein P6 interacts with the COP9 signalosome subunit 5 (LsCSN5) of SBPHs and suppresses LsCSN5-regulated de-neddylation from the Cullin 1 (CUL1), hereby inhibiting CUL1-based E3 ligases-mediated degradation of the circadian clock protein Timeless (TIM). Thus, virus infection or knockdown of LsCSN5 compromises TIM oscillation and induces high insect locomotor activity for transmission. Additionally, expression of BYSMV P6 in the CNS of transgenic Drosophila melanogaster disturbs circadian rhythm and induces high locomotor activity. Together, our results suggest the molecular mechanisms whereby BYSMV modulates locomotor activity of insect vectors for transmission.

Date: 2023
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DOI: 10.1038/s41467-023-41503-3

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