Plasma metabolomic profiles associated with mortality and longevity in a prospective analysis of 13,512 individuals

Fenglei Wang, Anne-Julie Tessier, Liming Liang, Clemens Wittenbecher, Danielle E. Haslam, Gonzalo Fernández-Duval, A. Heather Eliassen, Kathryn M. Rexrode, Deirdre K. Tobias, Jun Li, Oana Zeleznik, Francine Grodstein, Miguel A. Martínez-González, Jordi Salas-Salvadó, Clary Clish, Kyu Ha Lee, Qi Sun, Meir J. Stampfer, Frank B. Hu () and Marta Guasch-Ferré ()
Additional contact information
Fenglei Wang: Harvard T.H. Chan School of Public Health
Anne-Julie Tessier: Harvard T.H. Chan School of Public Health
Liming Liang: Harvard T.H. Chan School of Public Health
Clemens Wittenbecher: Harvard T.H. Chan School of Public Health
Danielle E. Haslam: Harvard T.H. Chan School of Public Health
Gonzalo Fernández-Duval: University of Navarra
A. Heather Eliassen: Harvard T.H. Chan School of Public Health
Kathryn M. Rexrode: Brigham and Women’s Hospital and Harvard Medical School
Deirdre K. Tobias: Harvard T.H. Chan School of Public Health
Jun Li: Harvard T.H. Chan School of Public Health
Oana Zeleznik: Brigham and Women’s Hospital and Harvard Medical School
Francine Grodstein: Rush University Medical Center
Miguel A. Martínez-González: Harvard T.H. Chan School of Public Health
Jordi Salas-Salvadó: Instituto de Salud Carlos III (ISCIII)
Clary Clish: Broad Institute of MIT and Harvard
Kyu Ha Lee: Harvard T.H. Chan School of Public Health
Qi Sun: Harvard T.H. Chan School of Public Health
Meir J. Stampfer: Harvard T.H. Chan School of Public Health
Frank B. Hu: Harvard T.H. Chan School of Public Health
Marta Guasch-Ferré: Harvard T.H. Chan School of Public Health

Nature Communications, 2023, vol. 14, issue 1, 1-11

Abstract: Abstract Experimental studies reported biochemical actions underpinning aging processes and mortality, but the relevant metabolic alterations in humans are not well understood. Here we examine the associations of 243 plasma metabolites with mortality and longevity (attaining age 85 years) in 11,634 US (median follow-up of 22.6 years, with 4288 deaths) and 1878 Spanish participants (median follow-up of 14.5 years, with 525 deaths). We find that, higher levels of N2,N2-dimethylguanosine, pseudouridine, N4-acetylcytidine, 4-acetamidobutanoic acid, N1-acetylspermidine, and lipids with fewer double bonds are associated with increased risk of all-cause mortality and reduced odds of longevity; whereas L-serine and lipids with more double bonds are associated with lower mortality risk and a higher likelihood of longevity. We further develop a multi-metabolite profile score that is associated with higher mortality risk. Our findings suggest that differences in levels of nucleosides, amino acids, and several lipid subclasses can predict mortality. The underlying mechanisms remain to be determined.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-023-41515-z Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41515-z

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-41515-z

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().