Histidine modulates amyloid-like assembly of peptide nanomaterials and confers enzyme-like activity

Ye Yuan, Lei Chen, Lingfei Kong, Lingling Qiu, Zhendong Fu, Minmin Sun, Yuan Liu, Miaomiao Cheng, Saiyu Ma, Xiaonan Wang, Changhui Zhao, Jing Jiang, Xinzheng Zhang, Liping Wang () and Lizeng Gao ()
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Ye Yuan: School of Life Sciences, Jilin University
Lei Chen: Institute of Biophysics, Chinese Academy of Sciences
Lingfei Kong: Institute of Biophysics, Chinese Academy of Sciences
Lingling Qiu: Yangzhou University
Zhendong Fu: School of Life Sciences, Jilin University
Minmin Sun: Institute of Biophysics, Chinese Academy of Sciences
Yuan Liu: Zhengzhou University
Miaomiao Cheng: Zhengzhou University
Saiyu Ma: Zhengzhou University
Xiaonan Wang: Institute of Biophysics, Chinese Academy of Sciences
Changhui Zhao: School of Life Sciences, Jilin University
Jing Jiang: Institute of Biophysics, Chinese Academy of Sciences
Xinzheng Zhang: Institute of Biophysics, Chinese Academy of Sciences
Liping Wang: School of Life Sciences, Jilin University
Lizeng Gao: Institute of Biophysics, Chinese Academy of Sciences

Nature Communications, 2023, vol. 14, issue 1, 1-12

Abstract: Abstract Amyloid-like assembly is not only associated with pathological events, but also leads to the development of novel nanomaterials with unique properties. Herein, using Fmoc diphenylalanine peptide (Fmoc–F–F) as a minimalistic model, we found that histidine can modulate the assembly behavior of Fmoc–F–F and induce enzyme-like catalysis. Specifically, the presence of histidine rearranges the β structure of Fmoc–F–F to assemble nanofilaments, resulting in the formation of active site to mimic peroxidase-like activity that catalyzes ROS generation. A similar catalytic property is also observed in Aβ assembled filaments, which is correlated with the spatial proximity between intermolecular histidine and F-F. Notably, the assembled Aβ filaments are able to induce cellular ROS elevation and damage neuron cells, providing an insight into the pathological relationship between Aβ aggregation and Alzheimer’s disease. These findings highlight the potential of histidine as a modulator in amyloid-like assembly of peptide nanomaterials exerting enzyme-like catalysis.

Date: 2023
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DOI: 10.1038/s41467-023-41591-1

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