Injectable and biodegradable piezoelectric hydrogel for osteoarthritis treatment

Tra Vinikoor, Godwin K. Dzidotor, Thinh T. Le, Yang Liu, Ho-Man Kan, Srimanta Barui, Meysam T. Chorsi, Eli J. Curry, Emily Reinhardt, Hanzhang Wang, Parbeen Singh, Marc A. Merriman, Ethan D’Orio, Jinyoung Park, Shuyang Xiao, James H. Chapman, Feng Lin, Cao-Sang Truong, Somasundaram Prasadh, Lisa Chuba, Shaelyn Killoh, Seok-Woo Lee, Qian Wu, Ramaswamy M. Chidambaram, Kevin W. H. Lo, Cato T. Laurencin and Thanh D. Nguyen ()
Additional contact information
Tra Vinikoor: University of Connecticut
Godwin K. Dzidotor: University of Connecticut Health
Thinh T. Le: University of Connecticut
Yang Liu: Center of Digital Dentistry/Department of Prosthodontics/Central Laboratory, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Research Center of Engineering and Technology for Computerized Dentistry & NMPA Key Laboratory for Dental Materials
Ho-Man Kan: University of Connecticut Health
Srimanta Barui: University of Connecticut Health
Meysam T. Chorsi: University of Connecticut
Eli J. Curry: Eli Lilly and Company
Emily Reinhardt: University of Connecticut
Hanzhang Wang: University of Connecticut Health Center
Parbeen Singh: University of Connecticut
Marc A. Merriman: University of Connecticut Health
Ethan D’Orio: University of Connecticut
Jinyoung Park: University of Connecticut
Shuyang Xiao: University of Connecticut
James H. Chapman: University of Connecticut Health
Feng Lin: University of Connecticut
Cao-Sang Truong: University of Connecticut
Somasundaram Prasadh: University of Connecticut
Lisa Chuba: University of Connecticut Health Center
Shaelyn Killoh: University of Connecticut Health Center
Seok-Woo Lee: University of Connecticut
Qian Wu: University of Connecticut Health Center
Ramaswamy M. Chidambaram: University of Connecticut Health Center
Kevin W. H. Lo: University of Connecticut Health
Cato T. Laurencin: University of Connecticut
Thanh D. Nguyen: University of Connecticut

Nature Communications, 2023, vol. 14, issue 1, 1-18

Abstract: Abstract Osteoarthritis affects millions of people worldwide but current treatments using analgesics or anti-inflammatory drugs only alleviate symptoms of this disease. Here, we present an injectable, biodegradable piezoelectric hydrogel, made of short electrospun poly-L-lactic acid nanofibers embedded inside a collagen matrix, which can be injected into the joints and self-produce localized electrical cues under ultrasound activation to drive cartilage healing. In vitro, data shows that the piezoelectric hydrogel with ultrasound can enhance cell migration and induce stem cells to secrete TGF-β1, which promotes chondrogenesis. In vivo, the rabbits with osteochondral critical-size defects receiving the ultrasound-activated piezoelectric hydrogel show increased subchondral bone formation, improved hyaline-cartilage structure, and good mechanical properties, close to healthy native cartilage. This piezoelectric hydrogel is not only useful for cartilage healing but also potentially applicable to other tissue regeneration, offering a significant impact on the field of regenerative tissue engineering.

Date: 2023
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DOI: 10.1038/s41467-023-41594-y

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