Synthesis of a covalent organic framework with hetero-environmental pores and its medicine co-delivery application

Wenyan Ji, Pai Zhang, Guangyuan Feng, Yuan-Zhe Cheng, Tian-Xiong Wang, Daqiang Yuan, Ruitao Cha (), Xuesong Ding (), Shengbin Lei () and Bao-Hang Han ()
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Wenyan Ji: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
Pai Zhang: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
Guangyuan Feng: Tianjin University
Yuan-Zhe Cheng: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
Tian-Xiong Wang: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
Daqiang Yuan: Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences (CAS)
Ruitao Cha: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
Xuesong Ding: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
Shengbin Lei: Tianjin University
Bao-Hang Han: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology

Nature Communications, 2023, vol. 14, issue 1, 1-10

Abstract: Abstract The topology type and the functionalization of pores play an important role in regulating the performance of covalent organic frameworks. Herein, we designed and synthesized the covalent organic framework with hetero-environmental pores using predesigned asymmetrical dialdehyde monomer. According to the results of structural characterization, crystallinity investigation, and theoretical calculation, the hetero-environmental pores of the obtained framework are regarded as the alternant arrangement. The distinctive hetero pore structure leads the designed material to show more advantages as compared with control materials in loading both hydrophobic and hydrophilic antibiotics for wound healing. This dual-antibiotic strategy can expand the antibacterial range as compared with the single antibiotic one, and reduce the generation of drug resistance. In summary, this strategy for designing covalent organic frameworks with hetero-environmental pores can extend the structural variety and provide a pathway for improving the practical application performance of these materials.

Date: 2023
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DOI: 10.1038/s41467-023-41622-x

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