Time-dependent memory transformation in hippocampus and neocortex is semantic in nature

Valentina Krenz, Arjen Alink, Tobias Sommer, Benno Roozendaal and Lars Schwabe ()
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Valentina Krenz: Universität Hamburg
Arjen Alink: Universität Hamburg
Tobias Sommer: University Medical Centre Hamburg-Eppendorf
Benno Roozendaal: Radboud University Medical Center
Lars Schwabe: Universität Hamburg

Nature Communications, 2023, vol. 14, issue 1, 1-17

Abstract: Abstract Memories undergo a time-dependent neural reorganization, which is assumed to be accompanied by a transformation from detailed to more gist-like memory. However, the nature of this transformation and its underlying neural mechanisms are largely unknown. Here, we report that the time-dependent transformation of memory is semantic in nature, while we find no credible evidence for a perceptual transformation. Model-based MRI analyses reveal time-dependent increases in semantically transformed representations of events in prefrontal and parietal cortices, while specific pattern representations in the anterior hippocampus decline over time. Posterior hippocampal memory reinstatement, in turn, increases over time and is linked to the semantic gist of the original memory, without a statistically significant link to perceptual details. These findings indicate that qualitative changes in memory over time, associated with distinct representational changes in the neocortex and within the hippocampus, reflect a semantic transformation, which may promote the integration of memories into abstract knowledge structures.

Date: 2023
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DOI: 10.1038/s41467-023-41648-1

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