Non-uniform temporal scaling of developmental processes in the mammalian cortex

Annalisa Paolino, Elizabeth H. Haines, Evan J. Bailey, Dylan A. Black, Ching Moey, Fernando García-Moreno, Linda J. Richards, Rodrigo Suárez () and Laura R. Fenlon ()
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Annalisa Paolino: The University of Queensland, School of Biomedical Sciences
Elizabeth H. Haines: The University of Queensland, School of Biomedical Sciences
Evan J. Bailey: The University of Queensland, School of Biomedical Sciences
Dylan A. Black: The University of Queensland, Queensland Brain Institute
Ching Moey: The University of Queensland, Queensland Brain Institute
Fernando García-Moreno: Scientific Park of the University of the Basque Country (UPV/EHU)
Linda J. Richards: The University of Queensland, School of Biomedical Sciences
Rodrigo Suárez: The University of Queensland, School of Biomedical Sciences
Laura R. Fenlon: The University of Queensland, School of Biomedical Sciences

Nature Communications, 2023, vol. 14, issue 1, 1-17

Abstract: Abstract The time that it takes the brain to develop is highly variable across animals. Although staging systems equate major developmental milestones between mammalian species, it remains unclear how distinct processes of cortical development scale within these timeframes. Here, we compare the timing of cortical development in two mammals of similar size but different developmental pace: eutherian mice and marsupial fat-tailed dunnarts. Our results reveal that the temporal relationship between cell birth and laminar specification aligns to equivalent stages between these species, but that migration and axon extension do not scale uniformly according to the developmental stages, and are relatively more advanced in dunnarts. We identify a lack of basal intermediate progenitor cells in dunnarts that likely contributes in part to this timing difference. These findings demonstrate temporal limitations and differential plasticity of cortical developmental processes between similarly sized Therians and provide insight into subtle temporal changes that may have contributed to the early diversification of the mammalian brain.

Date: 2023
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DOI: 10.1038/s41467-023-41652-5

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