Neurophysiological signatures of cortical micro-architecture

Golia Shafiei, Ben D. Fulcher, Bradley Voytek, Theodore D. Satterthwaite, Sylvain Baillet and Bratislav Misic ()
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Golia Shafiei: McGill University
Ben D. Fulcher: The University of Sydney
Bradley Voytek: University of California, San Diego
Theodore D. Satterthwaite: University of Pennsylvania
Sylvain Baillet: McGill University
Bratislav Misic: McGill University

Nature Communications, 2023, vol. 14, issue 1, 1-15

Abstract: Abstract Systematic spatial variation in micro-architecture is observed across the cortex. These micro-architectural gradients are reflected in neural activity, which can be captured by neurophysiological time-series. How spontaneous neurophysiological dynamics are organized across the cortex and how they arise from heterogeneous cortical micro-architecture remains unknown. Here we extensively profile regional neurophysiological dynamics across the human brain by estimating over 6800 time-series features from the resting state magnetoencephalography (MEG) signal. We then map regional time-series profiles to a comprehensive multi-modal, multi-scale atlas of cortical micro-architecture, including microstructure, metabolism, neurotransmitter receptors, cell types and laminar differentiation. We find that the dominant axis of neurophysiological dynamics reflects characteristics of power spectrum density and linear correlation structure of the signal, emphasizing the importance of conventional features of electromagnetic dynamics while identifying additional informative features that have traditionally received less attention. Moreover, spatial variation in neurophysiological dynamics is co-localized with multiple micro-architectural features, including gene expression gradients, intracortical myelin, neurotransmitter receptors and transporters, and oxygen and glucose metabolism. Collectively, this work opens new avenues for studying the anatomical basis of neural activity.

Date: 2023
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DOI: 10.1038/s41467-023-41689-6

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