Photostimulation of brain lymphatics in male newborn and adult rodents for therapy of intraventricular hemorrhage

Dongyu Li, Shaojun Liu, Tingting Yu (), Zhang Liu, Silin Sun, Denis Bragin, Alexander Shirokov, Nikita Navolokin, Olga Bragina, Zhengwu Hu, Jürgen Kurths, Ivan Fedosov, Inna Blokhina, Alexander Dubrovski, Alexander Khorovodov, Andrey Terskov, Maria Tzoy, Oxana Semyachkina-Glushkovskaya () and Dan Zhu ()
Additional contact information
Dongyu Li: Huazhong University of Science and Technology
Shaojun Liu: Huazhong University of Science and Technology
Tingting Yu: Huazhong University of Science and Technology
Zhang Liu: Huazhong University of Science and Technology
Silin Sun: Huazhong University of Science and Technology
Denis Bragin: Lovelace Biomedical Research Institute
Alexander Shirokov: Russian Academy of Sciences
Nikita Navolokin: Saratov State University
Olga Bragina: Lovelace Biomedical Research Institute
Zhengwu Hu: Huazhong University of Science and Technology
Jürgen Kurths: Saratov State University
Ivan Fedosov: Saratov State University
Inna Blokhina: Saratov State University
Alexander Dubrovski: Saratov State University
Alexander Khorovodov: Saratov State University
Andrey Terskov: Saratov State University
Maria Tzoy: Saratov State University
Oxana Semyachkina-Glushkovskaya: Saratov State University
Dan Zhu: Huazhong University of Science and Technology

Nature Communications, 2023, vol. 14, issue 1, 1-20

Abstract: Abstract Intraventricular hemorrhage is one of the most fatal forms of brain injury that is a common complication of premature infants. However, the therapy of this type of hemorrhage is limited, and new strategies are needed to reduce hematoma expansion. Here we show that the meningeal lymphatics is a pathway to remove red blood cells from the brain’s ventricular system of male human, adult and newborn rodents and is a target for non-invasive transcranial near infrared photobiomodulation. Our results uncover the clinical significance of phototherapy of intraventricular hemorrhage in 4-day old male rat pups that have the brain similar to a preterm human brain. The course of phototherapy in newborn rats provides fast recovery after intraventricular hemorrhage due to photo-improvements of lymphatic drainage and clearing functions. These findings shed light on the mechanisms of phototherapy of intraventricular hemorrhage that can be a clinically relevant technology for treatment of neonatal intracerebral bleedings.

Date: 2023
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DOI: 10.1038/s41467-023-41710-y

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