The leaderless communication peptide (LCP) class of quorum-sensing peptides is broadly distributed among Firmicutes

Shifu Aggarwal, Elaine Huang, Hackwon Do, Nishanth Makthal, Yanyan Li, Eric Bapteste, Philippe Lopez, Charles Bernard () and Muthiah Kumaraswami ()
Additional contact information
Shifu Aggarwal: Houston Methodist Research Institute
Elaine Huang: Houston Methodist Research Institute
Hackwon Do: Houston Methodist Research Institute
Nishanth Makthal: Houston Methodist Research Institute
Yanyan Li: Muséum National d’Histoire Naturelle
Eric Bapteste: Sorbonne Université, CNRS, Muséum National d’Histoire Naturelle
Philippe Lopez: Sorbonne Université, CNRS, Muséum National d’Histoire Naturelle
Charles Bernard: University of Lausanne
Muthiah Kumaraswami: Houston Methodist Research Institute

Nature Communications, 2023, vol. 14, issue 1, 1-13

Abstract: Abstract The human pathogen Streptococcus pyogenes secretes a short peptide (leaderless communication peptide, LCP) that mediates intercellular communication and controls bacterial virulence through interaction with its receptor, RopB. Here, we show that LCP and RopB homologues are present in other Firmicutes. We experimentally validate that LCPs with distinct peptide communication codes act as bacterial intercellular signals and regulate gene expression in Streptococcus salivarius, Streptococcus porcinus, Enterococcus malodoratus and Limosilactobacillus reuteri. Our results indicate that LCPs are more widespread than previously thought, and their characterization may uncover new signaling mechanisms and roles in coordinating diverse bacterial traits.

Date: 2023
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DOI: 10.1038/s41467-023-41719-3

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