The medial septum controls hippocampal supra-theta oscillations

Bálint Király, Andor Domonkos, Márta Jelitai, Vítor Lopes-dos-Santos, Sergio Martínez-Bellver, Barnabás Kocsis, Dániel Schlingloff, Abhilasha Joshi, Minas Salib, Richárd Fiáth, Péter Barthó, István Ulbert, Tamás F. Freund, Tim J. Viney, David Dupret, Viktor Varga and Balázs Hangya ()
Additional contact information
Bálint Király: Institute of Experimental Medicine
Andor Domonkos: Institute of Experimental Medicine
Márta Jelitai: Institute of Experimental Medicine
Vítor Lopes-dos-Santos: University of Oxford
Sergio Martínez-Bellver: Institute of Experimental Medicine
Barnabás Kocsis: Institute of Experimental Medicine
Dániel Schlingloff: Institute of Experimental Medicine
Abhilasha Joshi: University of Oxford
Minas Salib: University of Oxford
Richárd Fiáth: Pázmány Péter Catholic University
Péter Barthó: Research Centre for Natural Sciences
István Ulbert: Pázmány Péter Catholic University
Tamás F. Freund: Institute of Experimental Medicine
Tim J. Viney: University of Oxford
David Dupret: University of Oxford
Viktor Varga: Institute of Experimental Medicine
Balázs Hangya: Institute of Experimental Medicine

Nature Communications, 2023, vol. 14, issue 1, 1-25

Abstract: Abstract Hippocampal theta oscillations orchestrate faster beta-to-gamma oscillations facilitating the segmentation of neural representations during navigation and episodic memory. Supra-theta rhythms of hippocampal CA1 are coordinated by local interactions as well as inputs from the entorhinal cortex (EC) and CA3 inputs. However, theta-nested gamma-band activity in the medial septum (MS) suggests that the MS may control supra-theta CA1 oscillations. To address this, we performed multi-electrode recordings of MS and CA1 activity in rodents and found that MS neuron firing showed strong phase-coupling to theta-nested supra-theta episodes and predicted changes in CA1 beta-to-gamma oscillations on a cycle-by-cycle basis. Unique coupling patterns of anatomically defined MS cell types suggested that indirect MS-to-CA1 pathways via the EC and CA3 mediate distinct CA1 gamma-band oscillations. Optogenetic activation of MS parvalbumin-expressing neurons elicited theta-nested beta-to-gamma oscillations in CA1. Thus, the MS orchestrates hippocampal network activity at multiple temporal scales to mediate memory encoding and retrieval.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-023-41746-0 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41746-0

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-41746-0

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().