Hypersensitive MR angiography based on interlocking stratagem for diagnosis of cardiac-cerebral vascular diseases

Peisen Zhang, Junwei Cheng, Yijie Lu, Ni Zhang, Xiaoai Wu, Hua Lin, Wei Li (), Jian Wang, Mitchell A. Winnik, Zhihua Gan () and Yi Hou ()
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Peisen Zhang: Beijing University of Chemical Technology
Junwei Cheng: Beijing University of Chemical Technology
Yijie Lu: University of Toronto
Ni Zhang: Sichuan University
Xiaoai Wu: Sichuan University
Hua Lin: Sichuan University
Wei Li: Naval Medical University
Jian Wang: Peking Union Medical College
Mitchell A. Winnik: University of Toronto
Zhihua Gan: Beijing University of Chemical Technology
Yi Hou: Beijing University of Chemical Technology

Nature Communications, 2023, vol. 14, issue 1, 1-19

Abstract: Abstract Magnetic resonance (MR) angiography is one of the main diagnostic approaches for cardiac-cerebral vascular diseases. Nevertheless, the non-contrast-enhanced MR angiography suffers from its intrinsic problems derived from the blood flow-dependency, while the clinical Gd-chelating contrast agents are limited by their rapid vascular extravasation. Herein, we report a hypersensitive MR angiography strategy based on interlocking stratagem of zwitterionic Gd-chelate contrast agents (PAA-Gd). The longitudinal molar relaxivity of PAA-Gd was 4.6-times higher than that of individual Gd-chelates as well as appropriate blood half-life (73.8 min) and low immunogenicity, enabling sophisticated micro-vessels angiography with a resolution at the order of hundred micrometers. A series of animal models of cardiac-cerebrovascular diseases have been built for imaging studies on a 7.0 T MRI scanner, while the clinical translation potential of PAA-Gd has been evaluated on swine on a 3.0 T clinical MRI scanner. The current studies offer a promising strategy for precise diagnosis of vascular diseases.

Date: 2023
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DOI: 10.1038/s41467-023-41783-9

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