Cloning of the wheat leaf rust resistance gene Lr47 introgressed from Aegilops speltoides

Hongna Li, Lei Hua, Shuqing Zhao, Ming Hao, Rui Song, Shuyong Pang, Yanna Liu, Hong Chen, Wenjun Zhang, Tao Shen, Jin-Ying Gou, Hailiang Mao, Guiping Wang, Xiaohua Hao, Jian Li, Baoxing Song, Caixia Lan, Zaifeng Li, Xing Wang Deng, Jorge Dubcovsky, Xiaodong Wang () and Shisheng Chen ()
Additional contact information
Hongna Li: Peking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agricultural Sciences in Weifang
Lei Hua: Peking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agricultural Sciences in Weifang
Shuqing Zhao: Hebei Agricultural University
Ming Hao: Sichuan Agricultural University
Rui Song: Peking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agricultural Sciences in Weifang
Shuyong Pang: Peking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agricultural Sciences in Weifang
Yanna Liu: Peking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agricultural Sciences in Weifang
Hong Chen: Sichuan Agricultural University
Wenjun Zhang: University of California
Tao Shen: Peking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agricultural Sciences in Weifang
Jin-Ying Gou: China Agricultural University
Hailiang Mao: Huazhong Agricultural University
Guiping Wang: Peking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agricultural Sciences in Weifang
Xiaohua Hao: Peking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agricultural Sciences in Weifang
Jian Li: Peking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agricultural Sciences in Weifang
Baoxing Song: Peking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agricultural Sciences in Weifang
Caixia Lan: Huazhong Agricultural University
Zaifeng Li: Hebei Agricultural University
Xing Wang Deng: Peking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agricultural Sciences in Weifang
Jorge Dubcovsky: University of California
Xiaodong Wang: Hebei Agricultural University
Shisheng Chen: Peking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agricultural Sciences in Weifang

Nature Communications, 2023, vol. 14, issue 1, 1-15

Abstract: Abstract Leaf rust, caused by Puccinia triticina Eriksson (Pt), is one of the most severe foliar diseases of wheat. Breeding for leaf rust resistance is a practical and sustainable method to control this devastating disease. Here, we report the identification of Lr47, a broadly effective leaf rust resistance gene introgressed into wheat from Aegilops speltoides. Lr47 encodes a coiled-coil nucleotide-binding leucine-rich repeat protein that is both necessary and sufficient to confer Pt resistance, as demonstrated by loss-of-function mutations and transgenic complementation. Lr47 introgression lines with no or reduced linkage drag are generated using the Pairing homoeologous1 mutation, and a diagnostic molecular marker for Lr47 is developed. The coiled-coil domain of the Lr47 protein is unable to induce cell death, nor does it have self-protein interaction. The cloning of Lr47 expands the number of leaf rust resistance genes that can be incorporated into multigene transgenic cassettes to control this devastating disease.

Date: 2023
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DOI: 10.1038/s41467-023-41833-2

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