Domain adapted brain network fusion captures variance related to pubertal brain development and mental health

Dominik Kraft (), Dag Alnæs and Tobias Kaufmann ()
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Dominik Kraft: University of Tübingen
Dag Alnæs: University of Oslo and Oslo University Hospital
Tobias Kaufmann: University of Tübingen

Nature Communications, 2023, vol. 14, issue 1, 1-10

Abstract: Abstract Puberty demarks a period of profound brain dynamics that orchestrates changes to a multitude of neuroimaging-derived phenotypes. This complexity poses a dimensionality problem when attempting to chart an individual’s brain development over time. Here, we illustrate that shifts in subject similarity of brain imaging data relate to pubertal maturation in the longitudinal ABCD study. Given that puberty depicts a critical window for emerging mental health issues, we additionally show that our model is capable of capturing variance in the adolescent brain related to psychopathology in a population-based and a clinical cohort. These results suggest that low-dimensional reference spaces based on subject similarities render useful to chart variance in brain development in youths.

Date: 2023
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DOI: 10.1038/s41467-023-41839-w

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