Long-term health impacts of COVID-19 among 242,712 adults in England

Christina J. Atchison, Bethan Davies, Emily Cooper, Adam Lound, Matthew Whitaker, Adam Hampshire, Adriana Azor, Christl A. Donnelly, Marc Chadeau-Hyam, Graham S. Cooke, Helen Ward and Paul Elliott ()
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Christina J. Atchison: Imperial College London
Bethan Davies: Imperial College London
Emily Cooper: Imperial College London
Adam Lound: Imperial College London
Matthew Whitaker: Imperial College London
Adam Hampshire: Imperial College London
Adriana Azor: Imperial College London
Christl A. Donnelly: Imperial College London
Marc Chadeau-Hyam: Imperial College London
Graham S. Cooke: Imperial College Healthcare NHS Trust
Helen Ward: Imperial College London
Paul Elliott: Imperial College London

Nature Communications, 2023, vol. 14, issue 1, 1-10

Abstract: Abstract The COVID-19 pandemic is having a lasting impact on health and well-being. We compare current self-reported health, quality of life and symptom profiles for people with ongoing symptoms following COVID-19 to those who have never tested positive for SARS-CoV-2 infection and those who have recovered from COVID-19. Overall, 276,840/800,000 (34·6%) of invited participants took part. Mental health and health-related quality of life were worse among participants with ongoing persistent symptoms post-COVID compared with those who had never had COVID-19 or had recovered. In this study, median duration of COVID-related symptoms (N = 130,251) was 1·3 weeks (inter-quartile range 6 days to 2 weeks), with 7·5% and 5·2% reporting ongoing symptoms ≥12 weeks and ≥52 weeks respectively. Female sex, ≥1 comorbidity and being infected when Wild-type variant was dominant were associated with higher probability of symptoms lasting ≥12 weeks and longer recovery time in those with persistent symptoms. Although COVID-19 is usually of short duration, some adults experience persistent and burdensome illness.

Date: 2023
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DOI: 10.1038/s41467-023-41879-2

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