The Personalized Nutrition Study (POINTS): evaluation of a genetically informed weight loss approach, a Randomized Clinical Trial

Christoph Höchsmann (), Shengping Yang, José M. Ordovás, James L. Dorling, Catherine M. Champagne, John W. Apolzan, Frank L. Greenway, Michelle I. Cardel, Gary D. Foster and Corby K. Martin
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Christoph Höchsmann: Technical University of Munich
Shengping Yang: Pennington Biomedical Research Center
José M. Ordovás: Tufts University
James L. Dorling: University of Glasgow
Catherine M. Champagne: Pennington Biomedical Research Center
John W. Apolzan: Pennington Biomedical Research Center
Frank L. Greenway: Pennington Biomedical Research Center
Michelle I. Cardel: WW International, Inc.
Gary D. Foster: WW International, Inc.
Corby K. Martin: Pennington Biomedical Research Center

Nature Communications, 2023, vol. 14, issue 1, 1-13

Abstract: Abstract Weight loss (WL) differences between isocaloric high-carbohydrate and high-fat diets are generally small; however, individual WL varies within diet groups. Genotype patterns may modify diet effects, with carbohydrate-responsive genotypes losing more weight on high-carbohydrate diets (and vice versa for fat-responsive genotypes). We investigated whether 12-week WL (kg, primary outcome) differs between genotype-concordant and genotype-discordant diets. In this 12-week single-center WL trial, 145 participants with overweight/obesity were identified a priori as fat-responders or carbohydrate-responders based on their combined genotypes at ten genetic variants and randomized to a high-fat (n = 73) or high-carbohydrate diet (n = 72), yielding 4 groups: (1) fat-responders receiving high-fat diet, (2) fat-responders receiving high-carbohydrate diet, (3) carbohydrate-responders receiving high-fat diet, (4) carbohydrate-responders receiving high-carbohydrate diet. Dietitians delivered the WL intervention via 12 weekly diet-specific small group sessions. Outcome assessors were blind to diet assignment and genotype patterns. We included 122 participants (54.4 [SD:13.2] years, BMI 34.9 [SD:5.1] kg/m2, 84% women) in the analyses. Twelve-week WL did not differ between the genotype-concordant (−5.3 kg [SD:1.0]) and genotype-discordant diets (−4.8 kg [SD:1.1]; adjusted difference: −0.6 kg [95% CI: −2.1,0.9], p = 0.50). With the current ability to genotype participants as fat- or carbohydrate-responders, evidence does not support greater WL on genotype-concordant diets. ClinicalTrials identifier: NCT04145466.

Date: 2023
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DOI: 10.1038/s41467-023-41969-1

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