Comprehensive assessment of physiological responses in women during the ESA dry immersion VIVALDI microgravity simulation

Adrien Robin (), Angelique Ombergen, Claire Laurens, Audrey Bergouignan, Laurence Vico, Marie-Thérèse Linossier, Anne Pavy-Le Traon, Marc Kermorgant, Angèle Chopard, Guillaume Py, David Andrew Green, Michael Tipton, Alexander Choukér, Pierre Denise, Hervé Normand, Stéphane Blanc, Chantal Simon, Elisabeth Rosnet, Françoise Larcher, Peter Fernandez, Isabelle Glisezinski, Dominique Larrouy, Isabelle Harant-Farrugia, Inês Antunes, Guillemette Gauquelin-Koch, Marie-Pierre Bareille, Rebecca Billette De Villemeur, Marc-Antoine Custaud () and Nastassia Navasiolava ()
Additional contact information
Adrien Robin: Inserm, CNRS, MITOVASC, Equipe CARME, SFR ICAT
Angelique Ombergen: European Space Agency (ESA)
Claire Laurens: Paul Sabatier University
Audrey Bergouignan: University of Colorado
Laurence Vico: INSERM, University Jean Monnet, Mines Saint-Etienne
Marie-Thérèse Linossier: INSERM, University Jean Monnet, Mines Saint-Etienne
Anne Pavy-Le Traon: CHU Toulouse and I2MC-INSERM 1297
Marc Kermorgant: CHU Toulouse and I2MC-INSERM 1297
Angèle Chopard: DMEM, Montpellier University, INRAE
Guillaume Py: DMEM, Montpellier University, INRAE
David Andrew Green: King’s College London
Michael Tipton: University of Portsmouth
Alexander Choukér: Hospital of the Ludwig-Maximilians-University (LUM)
Pierre Denise: Inserm, COMETE U1075, CYCERON, CHU de Caen
Hervé Normand: Inserm, COMETE U1075, CYCERON, CHU de Caen
Stéphane Blanc: DEPE-IPHC - Département Ecologie, Physiologie et Ethologie
Chantal Simon: University Claude Bernard Lyon1, Human Nutrition Research Center Rhône-Alpes
Elisabeth Rosnet: Université de Reims Champagne-Ardenne
Françoise Larcher: Laboratoire de Biochimie, CHU d’Angers
Peter Fernandez: INSERM, University Jean Monnet, Mines Saint-Etienne
Isabelle Glisezinski: Paul Sabatier University
Dominique Larrouy: Paul Sabatier University
Isabelle Harant-Farrugia: Paul Sabatier University
Inês Antunes: Telespazio Belgium S.R.L. for the European Space Agency
Guillemette Gauquelin-Koch: Centre National d’Études Spatiales (CNES)
Marie-Pierre Bareille: Institute of Space Physiology and Medicine (MEDES)
Rebecca Billette De Villemeur: Institute of Space Physiology and Medicine (MEDES)
Marc-Antoine Custaud: Inserm, CNRS, MITOVASC, Equipe CARME, SFR ICAT
Nastassia Navasiolava: Inserm, CNRS, MITOVASC, Equipe CARME, SFR ICAT

Nature Communications, 2023, vol. 14, issue 1, 1-21

Abstract: Abstract Astronauts in microgravity experience multi-system deconditioning, impacting their inflight efficiency and inducing dysfunctions upon return to Earth gravity. To fill the sex gap of knowledge in the health impact of spaceflights, we simulate microgravity with a 5-day dry immersion in 18 healthy women (ClinicalTrials.gov Identifier: NCT05043974). Here we show that dry immersion rapidly induces a sedentarily-like metabolism shift mimicking the beginning of a metabolic syndrome with a drop in glucose tolerance, an increase in the atherogenic index of plasma, and an impaired lipid profile. Bone remodeling markers suggest a decreased bone formation coupled with an increased bone resorption. Fluid shifts and muscular unloading participate to a marked cardiovascular and sensorimotor deconditioning with decreased orthostatic tolerance, aerobic capacity, and postural balance. Collected datasets provide a comprehensive multi-systemic assessment of dry immersion effects in women and pave the way for future sex-based evaluations of countermeasures.

Date: 2023
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DOI: 10.1038/s41467-023-41990-4

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