Chronological adhesive cardiac patch for synchronous mechanophysiological monitoring and electrocoupling therapy

Chaojie Yu, Mingyue Shi, Shaoshuai He, Mengmeng Yao, Hong Sun (), Zhiwei Yue, Yuwei Qiu, Baijun Liu, Lei Liang, Zhongming Zhao, Fanglian Yao (), Hong Zhang () and Junjie Li ()
Additional contact information
Chaojie Yu: Tianjin University
Mingyue Shi: Tianjin University
Shaoshuai He: Tianjin University
Mengmeng Yao: Tianjin University
Hong Sun: North China University of Science and Technology
Zhiwei Yue: North China University of Science and Technology
Yuwei Qiu: Tianjin University
Baijun Liu: Tianjin University
Lei Liang: Tianjin University
Zhongming Zhao: Tianjin University
Fanglian Yao: Tianjin University
Hong Zhang: Tianjin University
Junjie Li: Tianjin University

Nature Communications, 2023, vol. 14, issue 1, 1-14

Abstract: Abstract With advances in tissue engineering and bioelectronics, flexible electronic hydrogels that allow conformal tissue integration, online precision diagnosis, and simultaneous tissue regeneration are expected to be the next-generation platform for the treatment of myocardial infarction. Here, we report a functionalized polyaniline-based chronological adhesive hydrogel patch (CAHP) that achieves spatiotemporally selective and conformal embedded integration with a moist and dynamic epicardium surface. Significantly, CAHP has high adhesion toughness, rapid self-healing ability, and enhanced electrochemical performance, facilitating sensitive sensing of cardiac mechanophysiology-mediated microdeformations and simultaneous improvement of myocardial fibrosis-induced electrophysiology. As a result, the flexible CAHP platform monitors diastolic-systolic amplitude and rhythm in the infarcted myocardium online while effectively inhibiting ventricular remodeling, promoting vascular regeneration, and improving electrophysiological function through electrocoupling therapy. Therefore, this diagnostic and therapeutic integration provides a promising monitorable treatment protocol for cardiac disease.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/s41467-023-42008-9 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42008-9

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-42008-9

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().