Developmental atlas of phase-amplitude coupling between physiologic high-frequency oscillations and slow waves

Kazuki Sakakura, Naoto Kuroda, Masaki Sonoda, Takumi Mitsuhashi, Ethan Firestone, Aimee F. Luat, Neena I. Marupudi, Sandeep Sood and Eishi Asano ()
Additional contact information
Kazuki Sakakura: Wayne State University
Naoto Kuroda: Wayne State University
Masaki Sonoda: Wayne State University
Takumi Mitsuhashi: Wayne State University
Ethan Firestone: Wayne State University
Aimee F. Luat: Wayne State University
Neena I. Marupudi: Wayne State University
Sandeep Sood: Wayne State University
Eishi Asano: Wayne State University

Nature Communications, 2023, vol. 14, issue 1, 1-13

Abstract: Abstract We investigated the developmental changes in high-frequency oscillation (HFO) and Modulation Index (MI) – the coupling measure between HFO and slow-wave phase. We generated normative brain atlases, using subdural EEG signals from 8251 nonepileptic electrode sites in 114 patients (ages 1.0–41.5 years) who achieved seizure control following resective epilepsy surgery. We observed a higher MI in the occipital lobe across all ages, and occipital MI increased notably during early childhood. The cortical areas exhibiting MI co-growth were connected via the vertical occipital fasciculi and posterior callosal fibers. While occipital HFO rate showed no significant age-association, the temporal, frontal, and parietal lobes exhibited an age-inversed HFO rate. Assessment of 1006 seizure onset sites revealed that z-score normalized MI and HFO rate were higher at seizure onset versus nonepileptic electrode sites. We have publicly shared our intracranial EEG data to enable investigators to validate MI and HFO-centric presurgical evaluations to identify the epileptogenic zone.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-023-42091-y Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42091-y

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-42091-y

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().