Electrophysiological population dynamics reveal context dependencies during decision making in human frontal cortex

Wan-Yu Shih (), Hsiang-Yu Yu, Cheng-Chia Lee, Chien-Chen Chou, Chien Chen, Paul W. Glimcher () and Shih-Wei Wu ()
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Wan-Yu Shih: National Yang Ming Chiao Tung University
Hsiang-Yu Yu: National Yang Ming Chiao Tung University
Cheng-Chia Lee: Taipei Veterans General Hospital
Chien-Chen Chou: National Yang Ming Chiao Tung University
Chien Chen: National Yang Ming Chiao Tung University
Paul W. Glimcher: NYU Grossman School of Medicine
Shih-Wei Wu: National Yang Ming Chiao Tung University

Nature Communications, 2023, vol. 14, issue 1, 1-24

Abstract: Abstract Evidence from monkeys and humans suggests that the orbitofrontal cortex (OFC) encodes the subjective value of options under consideration during choice. Data from non-human primates suggests that these value signals are context-dependent, representing subjective value in a way influenced by the decision makers’ recent experience. Using electrodes distributed throughout cortical and subcortical structures, human epilepsy patients performed an auction task where they repeatedly reported the subjective values they placed on snack food items. High-gamma activity in many cortical and subcortical sites including the OFC positively correlated with subjective value. Other OFC sites showed signals contextually modulated by the subjective value of previously offered goods—a context dependency predicted by theory but not previously observed in humans. These results suggest that value and value-context signals are simultaneously present but separately represented in human frontal cortical activity.

Date: 2023
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DOI: 10.1038/s41467-023-42092-x

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