Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria

Andrés D. Klein () and Tiago Fleming Outeiro ()
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Andrés D. Klein: Clínica Alemana Universidad del Desarrollo
Tiago Fleming Outeiro: University Medical Center Göttingen

Nature Communications, 2023, vol. 14, issue 1, 1-3

Abstract: β-Glucocerebrosidase (GCase) mutations lead to glucosylceramide build-up in the lysosome, impacting α-synuclein aggregation and autophagy. Recently, Baden and colleagues found GCase in mitochondria, supporting mitochondrial complex I function and energy metabolism. We believe the newly described role of GCase in the mitochondria will inform new Parkinson’s and Gaucher’s disease therapeutics.

Date: 2023
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DOI: 10.1038/s41467-023-42107-7

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