Subventricular zone cytogenesis provides trophic support for neural repair in a mouse model of stroke

Michael R. Williamson (), Stephanie P. Le, Ronald L. Franzen, Nicole A. Donlan, Jill L. Rosow, Mathilda S. Nicot-Cartsonis, Alexis Cervantes, Benjamin Deneen, Andrew K. Dunn, Theresa A. Jones and Michael R. Drew
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Michael R. Williamson: University of Texas at Austin
Stephanie P. Le: University of Texas at Austin
Ronald L. Franzen: University of Texas at Austin
Nicole A. Donlan: University of Texas at Austin
Jill L. Rosow: University of Texas at Austin
Mathilda S. Nicot-Cartsonis: University of Texas Medical Branch at Galveston
Alexis Cervantes: Baylor College of Medicine
Benjamin Deneen: Baylor College of Medicine
Andrew K. Dunn: University of Texas at Austin
Theresa A. Jones: University of Texas at Austin
Michael R. Drew: University of Texas at Austin

Nature Communications, 2023, vol. 14, issue 1, 1-18

Abstract: Abstract Stroke enhances proliferation of neural precursor cells within the subventricular zone (SVZ) and induces ectopic migration of newborn cells towards the site of injury. Here, we characterize the identity of cells arising from the SVZ after stroke and uncover a mechanism through which they facilitate neural repair and functional recovery. With genetic lineage tracing, we show that SVZ-derived cells that migrate towards cortical photothrombotic stroke in mice are predominantly undifferentiated precursors. We find that ablation of neural precursor cells or conditional knockout of VEGF impairs neuronal and vascular reparative responses and worsens recovery. Replacement of VEGF is sufficient to induce neural repair and recovery. We also provide evidence that CXCL12 from peri-infarct vasculature signals to CXCR4-expressing cells arising from the SVZ to direct their ectopic migration. These results support a model in which vasculature surrounding the site of injury attracts cells from the SVZ, and these cells subsequently provide trophic support that drives neural repair and recovery.

Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42138-0

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DOI: 10.1038/s41467-023-42138-0

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