Synergistic investigation of natural and synthetic C1-trophic microorganisms to foster a circular carbon economy

Enrico Orsi, Pablo Ivan Nikel, Lars Keld Nielsen and Stefano Donati ()
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Enrico Orsi: Technical University of Denmark
Pablo Ivan Nikel: Technical University of Denmark
Lars Keld Nielsen: Technical University of Denmark
Stefano Donati: Technical University of Denmark

Nature Communications, 2023, vol. 14, issue 1, 1-9

Abstract: Abstract A true circular carbon economy must upgrade waste greenhouse gases. C1-based biomanufacturing is an attractive solution, in which one carbon (C1) molecules (e.g. CO2, formate, methanol, etc.) are converted by microbial cell factories into value-added goods (i.e. food, feed, and chemicals). To render C1-based biomanufacturing cost-competitive, we must adapt microbial metabolism to perform chemical conversions at high rates and yields. To this end, the biotechnology community has undertaken two (seemingly opposing) paths: optimizing natural C1-trophic microorganisms versus engineering synthetic C1-assimilation de novo in model microorganisms. Here, we pose how these approaches can instead create synergies for strengthening the competitiveness of C1-based biomanufacturing as a whole.

Date: 2023
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DOI: 10.1038/s41467-023-42166-w

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