A non-canonical striatopallidal Go pathway that supports motor control

Marie A. Labouesse (), Arturo Torres-Herraez, Muhammad O. Chohan, Joseph M. Villarin, Julia Greenwald, Xiaoxiao Sun, Mysarah Zahran, Alice Tang, Sherry Lam, Jeremy Veenstra-VanderWeele, Clay O. Lacefield, Jordi Bonaventura, Michael Michaelides, C. Savio Chan, Ofer Yizhar and Christoph Kellendonk ()
Additional contact information
Marie A. Labouesse: Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center
Arturo Torres-Herraez: Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center
Muhammad O. Chohan: Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center
Joseph M. Villarin: Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center
Julia Greenwald: Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center
Xiaoxiao Sun: New York State Psychiatric Institute
Mysarah Zahran: New York State Psychiatric Institute
Alice Tang: New York State Psychiatric Institute
Sherry Lam: National Institute on Drug Abuse Intramural Research Program
Jeremy Veenstra-VanderWeele: Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center
Clay O. Lacefield: Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center
Jordi Bonaventura: National Institute on Drug Abuse Intramural Research Program
Michael Michaelides: National Institute on Drug Abuse Intramural Research Program
C. Savio Chan: Northwestern University
Ofer Yizhar: Weizmann Institute of Science
Christoph Kellendonk: Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center

Nature Communications, 2023, vol. 14, issue 1, 1-20

Abstract: Abstract In the classical model of the basal ganglia, direct pathway striatal projection neurons (dSPNs) send projections to the substantia nigra (SNr) and entopeduncular nucleus to regulate motor function. Recent studies have re-established that dSPNs also possess axon collaterals within the globus pallidus (GPe) (bridging collaterals), yet the significance of these collaterals for behavior is unknown. Here we use in vivo optical and chemogenetic tools combined with deep learning approaches in mice to dissect the roles of dSPN GPe collaterals in motor function. We find that dSPNs projecting to the SNr send synchronous motor-related information to the GPe via axon collaterals. Inhibition of native activity in dSPN GPe terminals impairs motor activity and function via regulation of Npas1 neurons. We propose a model by which dSPN GPe axon collaterals (striatopallidal Go pathway) act in concert with the canonical terminals in the SNr to support motor control by inhibiting Npas1 neurons.

Date: 2023
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DOI: 10.1038/s41467-023-42288-1

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