Long-term cargo tracking reveals intricate trafficking through active cytoskeletal networks in the crowded cellular environment

Jin-Sung Park, Il-Buem Lee, Hyeon-Min Moon, Seok-Cheol Hong () and Minhaeng Cho ()
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Jin-Sung Park: Institute for Basic Science
Il-Buem Lee: Institute for Basic Science
Hyeon-Min Moon: Institute for Basic Science
Seok-Cheol Hong: Institute for Basic Science
Minhaeng Cho: Institute for Basic Science

Nature Communications, 2023, vol. 14, issue 1, 1-11

Abstract: Abstract A eukaryotic cell is a microscopic world within which efficient material transport is essential. Yet, how a cell manages to deliver cellular cargos efficiently in a crowded environment remains poorly understood. Here, we used interferometric scattering microscopy to track unlabeled cargos in directional motion in a massively parallel fashion. Our label-free, cargo-tracing method revealed not only the dynamics of cargo transportation but also the fine architecture of the actively used cytoskeletal highways and the long-term evolution of the associated traffic at sub-diffraction resolution. Cargos frequently run into a blocked road or experience a traffic jam. Still, they have effective strategies to circumvent those problems: opting for an alternative mode of transport and moving together in tandem or migrating collectively. All taken together, a cell is an incredibly complex and busy space where the principle and practice of transportation intriguingly parallel those of our macroscopic world.

Date: 2023
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DOI: 10.1038/s41467-023-42347-7

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