Ultra-high-throughput mapping of the chemical space of asymmetric catalysis enables accelerated reaction discovery

Wenjing Nie, Qiongqiong Wan, Jian Sun, Moran Chen, Ming Gao and Suming Chen ()
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Wenjing Nie: Wuhan University
Qiongqiong Wan: Wuhan University
Jian Sun: Wuhan University
Moran Chen: Wuhan University
Ming Gao: Wuhan University
Suming Chen: Wuhan University

Nature Communications, 2023, vol. 14, issue 1, 1-11

Abstract: Abstract The discovery of highly enantioselective catalysts and elucidating their generality face great challenges due to the complex multidimensional chemical space of asymmetric catalysis and inefficient screening methods. Here, we develop a general strategy for ultra-high-throughput mapping of the chemical space of asymmetric catalysis by escaping the time-consuming chiral chromatography separation. The ultrafast ( ~ 1000 reactions/day) and accurate (median error

Date: 2023
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DOI: 10.1038/s41467-023-42446-5

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