Systematic review and integrated data analysis reveal diverse pangolin-associated microbes with infection potential

Run-Ze Ye, Xiao-Yang Wang, Yu-Yu Li, Bao-Yu Wang, Ke Song, Yi-Fei Wang, Jing Liu, Bai-Hui Wang, Shan-Shan Wang, Qing Xu, Ze-Hui Li, Yi-Di Du, Jin-Yue Liu, Jia-Jing Zheng, Li-Feng Du, Wenqiang Shi, Na Jia, Jia-Fu Jiang, Xiao-Ming Cui (), Lin Zhao () and Wu-Chun Cao ()
Additional contact information
Run-Ze Ye: Shandong University
Xiao-Yang Wang: Shandong University
Yu-Yu Li: Shandong University
Bao-Yu Wang: Shandong University
Ke Song: Shandong University
Yi-Fei Wang: Shandong University
Jing Liu: Shandong University
Bai-Hui Wang: Shandong University
Shan-Shan Wang: Shandong University
Qing Xu: Shandong University
Ze-Hui Li: Shandong University
Yi-Di Du: Shandong University
Jin-Yue Liu: Shandong University
Jia-Jing Zheng: Beijing Institute of Microbiology and Epidemiology
Li-Feng Du: Shandong University
Wenqiang Shi: Beijing Institute of Microbiology and Epidemiology
Na Jia: Beijing Institute of Microbiology and Epidemiology
Jia-Fu Jiang: Beijing Institute of Microbiology and Epidemiology
Xiao-Ming Cui: Beijing Institute of Microbiology and Epidemiology
Lin Zhao: Shandong University
Wu-Chun Cao: Shandong University

Nature Communications, 2023, vol. 14, issue 1, 1-10

Abstract: Abstract There has been increasing global concern about the spillover transmission of pangolin-associated microbes. To assess the risk of these microbes for emergence as human pathogens, we integrated data from multiple sources to describe the distribution and spectrum of microbes harbored by pangolins. Wild and trafficked pangolins have been mainly recorded in Asia and Africa, while captive pangolins have been reported in European and North American countries. A total of 128 microbes, including 92 viruses, 25 bacteria, eight protists, and three uncharacterized microbes, have been identified in five pangolin species. Out of 128 pangolin-associated microbes, 31 (including 13 viruses, 15 bacteria, and three protists) have been reported in humans, and 54 are animal-associated viruses. The phylogenetic analysis of human-associated viruses carried by pangolins reveals that they are genetically close to those naturally circulating among human populations in the world. Pangolins harbor diverse microbes, many of which have been previously reported in humans and animals. Abundant viruses initially detected in pangolins might exhibit risks for spillover transmission.

Date: 2023
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DOI: 10.1038/s41467-023-42592-w

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