Transcriptional dissection of symptomatic profiles across the brain of men and women with depression

Samaneh Mansouri, André M. Pessoni, Arturo Marroquín-Rivera, Eric M. Parise, Carol A. Tamminga, Gustavo Turecki, Eric J. Nestler, Ting-Huei Chen and Benoit Labonté ()
Additional contact information
Samaneh Mansouri: CERVO Brain Research Centre
André M. Pessoni: CERVO Brain Research Centre
Arturo Marroquín-Rivera: CERVO Brain Research Centre
Eric M. Parise: Icahn School of Medicine at Mount Sinai, New York
Carol A. Tamminga: The University of Texas Southwestern Medical Center
Gustavo Turecki: Douglas Mental Health University Institute
Eric J. Nestler: Icahn School of Medicine at Mount Sinai, New York
Ting-Huei Chen: CERVO Brain Research Centre
Benoit Labonté: CERVO Brain Research Centre

Nature Communications, 2023, vol. 14, issue 1, 1-14

Abstract: Abstract Major depressive disorder (MDD) is one of the most important causes of disability worldwide. While recent work provides insights into the molecular alterations in the brain of patients with MDD, whether these molecular signatures can be associated with the expression of specific symptom domains remains unclear. Here, we identified sex-specific gene modules associated with the expression of MDD, combining differential gene expression and co-expression network analyses in six cortical and subcortical brain regions. Our results show varying levels of network homology between males and females across brain regions, although the associations between these structures and the expression of MDD remain highly sex specific. We refined these associations to several symptom domains and identified transcriptional signatures associated with distinct functional pathways, including GABAergic and glutamatergic neurotransmission, metabolic processes and intracellular signal transduction, across brain regions associated with distinct symptomatic profiles in a sex-specific fashion. In most cases, these associations were specific to males or to females with MDD, although a subset of gene modules associated with common symptomatic features in both sexes were also identified. Together, our findings suggest that the expression of distinct MDD symptom domains associates with sex-specific transcriptional structures across brain regions.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-023-42686-5 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42686-5

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-42686-5

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().